Coronin 1C inhibits melanoma metastasis through regulation of MT1-MMP-containing extracellular vesicle secretion

Coronin 1C is overexpressed in multiple tumors, leading to the widely held view that this gene drives tumor progression, but this hypothesis has not been rigorously tested in melanoma. Here, we combined a conditional knockout of Coronin 1C with a genetically engineered mouse model of PTEN/BRAF-drive...

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Detalles Bibliográficos
Autores principales: Tagliatela, Alicia C., Hempstead, Stephanie C., Hibshman, Priya S., Hockenberry, Max A., Brighton, Hailey E., Pecot, Chad V., Bear, James E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7371684/
https://www.ncbi.nlm.nih.gov/pubmed/32686704
http://dx.doi.org/10.1038/s41598-020-67465-w

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