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An OTX2-PAX3 signaling axis regulates Group 3 medulloblastoma cell fate

OTX2 is a potent oncogene that promotes tumor growth in Group 3 medulloblastoma. However, the mechanisms by which OTX2 represses neural differentiation are not well characterized. Here, we perform extensive multiomic analyses to identify an OTX2 regulatory network that controls Group 3 medulloblasto...

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Detalles Bibliográficos
Autores principales:	Zagozewski, Jamie, Shahriary, Ghazaleh M., Morrison, Ludivine Coudière, Saulnier, Olivier, Stromecki, Margaret, Fresnoza, Agnes, Palidwor, Gareth, Porter, Christopher J., Forget, Antoine, Ayrault, Olivier, Hawkins, Cynthia, Chan, Jennifer A., Vladoiu, Maria C., Sundaresan, Lakshmikirupa, Arsenio, Janilyn, Taylor, Michael D., Ramaswamy, Vijay, Werbowetski-Ogilvie, Tamra E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7371715/ https://www.ncbi.nlm.nih.gov/pubmed/32686664 http://dx.doi.org/10.1038/s41467-020-17357-4

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