Discovery of new fluorescent thiazole–pyrazoline derivatives as autophagy inducers by inhibiting mTOR activity in A549 human lung cancer cells

A series of fluorescent thiazole–pyrazoline derivatives was synthesized and their structures were characterized by (1)H NMR, (13)C NMR, and HRMS. Biological evaluation demonstrated that these compounds could effectively inhibit the growth of human non-small cell lung cancer (NSCLC) A549 cells in a d...

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Detalles Bibliográficos
Autores principales: Lin, ZhaoMin, Wang, ZhaoYang, Zhou, XueWen, Zhang, Ming, Gao, DongFang, Zhang, Lu, Wang, Peng, Chen, Yuan, Lin, YuXing, Zhao, BaoXiang, Miao, JunYing, Kong, Feng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7371735/
https://www.ncbi.nlm.nih.gov/pubmed/32686662
http://dx.doi.org/10.1038/s41419-020-02746-w

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