Cancer increases risk of in-hospital death from COVID-19 in persons <65 years and those not in complete remission

The impact of cancer on outcome of persons with coronavirus disease 2019 (COVID-19) after infection with acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is controversial. We studied 1859 subjects with COVID-19 from seven centers in Wuhan, China, 65 of whom had cancer. We found having cancer wa...

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Detalles Bibliográficos
Autores principales: Li, Qiubai, Chen, Lei, Li, Qin, He, Wenjuan, Yu, Jianming, Chen, Li, Cao, Yulin, Chen, Wenlan, Di Wu, Dong, Fang, Cai, Liling, Ran, Qijie, Li, Lei, Liu, Qiaomei, Ren, Wenxiang, Gao, Fei, Wang, Hongxiang, Chen, Zhichao, Gale, Robert Peter, Hu, Yu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7371786/
https://www.ncbi.nlm.nih.gov/pubmed/32690880
http://dx.doi.org/10.1038/s41375-020-0986-7
Descripción
Sumario:The impact of cancer on outcome of persons with coronavirus disease 2019 (COVID-19) after infection with acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is controversial. We studied 1859 subjects with COVID-19 from seven centers in Wuhan, China, 65 of whom had cancer. We found having cancer was an independent risk factor for in-hospital death from COVID-19 in persons <65 years (hazard ratio [HR] = 2.45, 95% confidence interval [CI], 1.04, 5.76; P = 0.041) but not in those ≥65 years (HR = 1.12 [0.56, 2.24]; P = 0.740). It was also more common in those not in complete remission. Risks of in-hospital death were similar in subjects with solid cancers and those with hematological cancers. These data may help predict outcomes of persons with cancer and COVID-19.

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