Cancer increases risk of in-hospital death from COVID-19 in persons <65 years and those not in complete remission

The impact of cancer on outcome of persons with coronavirus disease 2019 (COVID-19) after infection with acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is controversial. We studied 1859 subjects with COVID-19 from seven centers in Wuhan, China, 65 of whom had cancer. We found having cancer wa...

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Autores principales: Li, Qiubai, Chen, Lei, Li, Qin, He, Wenjuan, Yu, Jianming, Chen, Li, Cao, Yulin, Chen, Wenlan, Di Wu, Dong, Fang, Cai, Liling, Ran, Qijie, Li, Lei, Liu, Qiaomei, Ren, Wenxiang, Gao, Fei, Wang, Hongxiang, Chen, Zhichao, Gale, Robert Peter, Hu, Yu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7371786/
https://www.ncbi.nlm.nih.gov/pubmed/32690880
http://dx.doi.org/10.1038/s41375-020-0986-7
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author Li, Qiubai
Chen, Lei
Li, Qin
He, Wenjuan
Yu, Jianming
Chen, Li
Cao, Yulin
Chen, Wenlan
Di Wu
Dong, Fang
Cai, Liling
Ran, Qijie
Li, Lei
Liu, Qiaomei
Ren, Wenxiang
Gao, Fei
Wang, Hongxiang
Chen, Zhichao
Gale, Robert Peter
Hu, Yu
author_facet Li, Qiubai
Chen, Lei
Li, Qin
He, Wenjuan
Yu, Jianming
Chen, Li
Cao, Yulin
Chen, Wenlan
Di Wu
Dong, Fang
Cai, Liling
Ran, Qijie
Li, Lei
Liu, Qiaomei
Ren, Wenxiang
Gao, Fei
Wang, Hongxiang
Chen, Zhichao
Gale, Robert Peter
Hu, Yu
author_sort Li, Qiubai
collection PubMed
description The impact of cancer on outcome of persons with coronavirus disease 2019 (COVID-19) after infection with acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is controversial. We studied 1859 subjects with COVID-19 from seven centers in Wuhan, China, 65 of whom had cancer. We found having cancer was an independent risk factor for in-hospital death from COVID-19 in persons <65 years (hazard ratio [HR] = 2.45, 95% confidence interval [CI], 1.04, 5.76; P = 0.041) but not in those ≥65 years (HR = 1.12 [0.56, 2.24]; P = 0.740). It was also more common in those not in complete remission. Risks of in-hospital death were similar in subjects with solid cancers and those with hematological cancers. These data may help predict outcomes of persons with cancer and COVID-19.
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spelling pubmed-73717862020-07-21 Cancer increases risk of in-hospital death from COVID-19 in persons <65 years and those not in complete remission Li, Qiubai Chen, Lei Li, Qin He, Wenjuan Yu, Jianming Chen, Li Cao, Yulin Chen, Wenlan Di Wu Dong, Fang Cai, Liling Ran, Qijie Li, Lei Liu, Qiaomei Ren, Wenxiang Gao, Fei Wang, Hongxiang Chen, Zhichao Gale, Robert Peter Hu, Yu Leukemia Article The impact of cancer on outcome of persons with coronavirus disease 2019 (COVID-19) after infection with acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is controversial. We studied 1859 subjects with COVID-19 from seven centers in Wuhan, China, 65 of whom had cancer. We found having cancer was an independent risk factor for in-hospital death from COVID-19 in persons <65 years (hazard ratio [HR] = 2.45, 95% confidence interval [CI], 1.04, 5.76; P = 0.041) but not in those ≥65 years (HR = 1.12 [0.56, 2.24]; P = 0.740). It was also more common in those not in complete remission. Risks of in-hospital death were similar in subjects with solid cancers and those with hematological cancers. These data may help predict outcomes of persons with cancer and COVID-19. Nature Publishing Group UK 2020-07-20 2020 /pmc/articles/PMC7371786/ /pubmed/32690880 http://dx.doi.org/10.1038/s41375-020-0986-7 Text en © The Author(s), under exclusive licence to Springer Nature Limited 2020 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Article
Li, Qiubai
Chen, Lei
Li, Qin
He, Wenjuan
Yu, Jianming
Chen, Li
Cao, Yulin
Chen, Wenlan
Di Wu
Dong, Fang
Cai, Liling
Ran, Qijie
Li, Lei
Liu, Qiaomei
Ren, Wenxiang
Gao, Fei
Wang, Hongxiang
Chen, Zhichao
Gale, Robert Peter
Hu, Yu
Cancer increases risk of in-hospital death from COVID-19 in persons <65 years and those not in complete remission
title Cancer increases risk of in-hospital death from COVID-19 in persons <65 years and those not in complete remission
title_full Cancer increases risk of in-hospital death from COVID-19 in persons <65 years and those not in complete remission
title_fullStr Cancer increases risk of in-hospital death from COVID-19 in persons <65 years and those not in complete remission
title_full_unstemmed Cancer increases risk of in-hospital death from COVID-19 in persons <65 years and those not in complete remission
title_short Cancer increases risk of in-hospital death from COVID-19 in persons <65 years and those not in complete remission
title_sort cancer increases risk of in-hospital death from covid-19 in persons <65 years and those not in complete remission
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7371786/
https://www.ncbi.nlm.nih.gov/pubmed/32690880
http://dx.doi.org/10.1038/s41375-020-0986-7
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