Sequence analysis of nonulosonic acid biosynthetic gene clusters in Vibrionaceae and Moritella viscosa

Nonulosonic acid (NulO) biosynthesis in bacteria is directed by nab gene clusters that can lead to neuraminic, legionaminic or pseudaminic acids. Analysis of the gene content from a set mainly composed of Aliivibrio salmonicida and Moritella viscosa strains reveals the existence of several unique na...

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Autores principales: Halsør, Marie-Josée Haglund, Altermark, Bjørn, Ræder, Inger Lin Uttakleiv
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7371886/
https://www.ncbi.nlm.nih.gov/pubmed/32686701
http://dx.doi.org/10.1038/s41598-020-68492-3
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author Halsør, Marie-Josée Haglund
Altermark, Bjørn
Ræder, Inger Lin Uttakleiv
author_facet Halsør, Marie-Josée Haglund
Altermark, Bjørn
Ræder, Inger Lin Uttakleiv
author_sort Halsør, Marie-Josée Haglund
collection PubMed
description Nonulosonic acid (NulO) biosynthesis in bacteria is directed by nab gene clusters that can lead to neuraminic, legionaminic or pseudaminic acids. Analysis of the gene content from a set mainly composed of Aliivibrio salmonicida and Moritella viscosa strains reveals the existence of several unique nab clusters, for which the NulO products were predicted. This prediction method can be used to guide tandem mass spectrometry studies in order to verify the products of previously undescribed nab clusters and identify new members of the NulOs family.
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spelling pubmed-73718862020-07-22 Sequence analysis of nonulosonic acid biosynthetic gene clusters in Vibrionaceae and Moritella viscosa Halsør, Marie-Josée Haglund Altermark, Bjørn Ræder, Inger Lin Uttakleiv Sci Rep Article Nonulosonic acid (NulO) biosynthesis in bacteria is directed by nab gene clusters that can lead to neuraminic, legionaminic or pseudaminic acids. Analysis of the gene content from a set mainly composed of Aliivibrio salmonicida and Moritella viscosa strains reveals the existence of several unique nab clusters, for which the NulO products were predicted. This prediction method can be used to guide tandem mass spectrometry studies in order to verify the products of previously undescribed nab clusters and identify new members of the NulOs family. Nature Publishing Group UK 2020-07-20 /pmc/articles/PMC7371886/ /pubmed/32686701 http://dx.doi.org/10.1038/s41598-020-68492-3 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Halsør, Marie-Josée Haglund
Altermark, Bjørn
Ræder, Inger Lin Uttakleiv
Sequence analysis of nonulosonic acid biosynthetic gene clusters in Vibrionaceae and Moritella viscosa
title Sequence analysis of nonulosonic acid biosynthetic gene clusters in Vibrionaceae and Moritella viscosa
title_full Sequence analysis of nonulosonic acid biosynthetic gene clusters in Vibrionaceae and Moritella viscosa
title_fullStr Sequence analysis of nonulosonic acid biosynthetic gene clusters in Vibrionaceae and Moritella viscosa
title_full_unstemmed Sequence analysis of nonulosonic acid biosynthetic gene clusters in Vibrionaceae and Moritella viscosa
title_short Sequence analysis of nonulosonic acid biosynthetic gene clusters in Vibrionaceae and Moritella viscosa
title_sort sequence analysis of nonulosonic acid biosynthetic gene clusters in vibrionaceae and moritella viscosa
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7371886/
https://www.ncbi.nlm.nih.gov/pubmed/32686701
http://dx.doi.org/10.1038/s41598-020-68492-3
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