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KRAS(G12C)–AMG 510 interaction dynamics revealed by all-atom molecular dynamics simulations
The first KRAS(G12C) targeting inhibitor in clinical development, AMG 510, has shown promising antitumor activity in clinical trials. On the molecular level, however, the interaction dynamics of this covalently bound drug–protein complex has been undetermined. Here, we disclose the interaction dynam...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group UK
2020
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7371895/ https://www.ncbi.nlm.nih.gov/pubmed/32686745 http://dx.doi.org/10.1038/s41598-020-68950-y |