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KRAS(G12C)–AMG 510 interaction dynamics revealed by all-atom molecular dynamics simulations

The first KRAS(G12C) targeting inhibitor in clinical development, AMG 510, has shown promising antitumor activity in clinical trials. On the molecular level, however, the interaction dynamics of this covalently bound drug–protein complex has been undetermined. Here, we disclose the interaction dynam...

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Detalles Bibliográficos
Autor principal:	Pantsar, Tatu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7371895/ https://www.ncbi.nlm.nih.gov/pubmed/32686745 http://dx.doi.org/10.1038/s41598-020-68950-y

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