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Comparison of Noninvasive Imagery Methods to Observe Healthy and Degenerated Olfactory Epithelium in Mice for the Early Diagnosis of Neurodegenerative Diseases

Olfactory dysfunction could be an early and reliable indicator for the diagnosis of neurodegenerative disorders such as Alzheimer and Parkinson's diseases. In this paper, we compare the potential of different noninvasive medical imaging modalities (optical coherence tomography, confocal microsc...

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Autores principales: Etievant, Adeline, Monnin, Julie, Lihoreau, Thomas, Tamadazte, Brahim, Rougeot, Patrick, Magnin, Eloi, Tavernier, Laurent, Pazart, Lionel, Haffen, Emmanuel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7371997/
https://www.ncbi.nlm.nih.gov/pubmed/32760253
http://dx.doi.org/10.3389/fnana.2020.00034
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author Etievant, Adeline
Monnin, Julie
Lihoreau, Thomas
Tamadazte, Brahim
Rougeot, Patrick
Magnin, Eloi
Tavernier, Laurent
Pazart, Lionel
Haffen, Emmanuel
author_facet Etievant, Adeline
Monnin, Julie
Lihoreau, Thomas
Tamadazte, Brahim
Rougeot, Patrick
Magnin, Eloi
Tavernier, Laurent
Pazart, Lionel
Haffen, Emmanuel
author_sort Etievant, Adeline
collection PubMed
description Olfactory dysfunction could be an early and reliable indicator for the diagnosis of neurodegenerative disorders such as Alzheimer and Parkinson's diseases. In this paper, we compare the potential of different noninvasive medical imaging modalities (optical coherence tomography, confocal microscopy, and fluorescence endomicroscopy) to distinguish how the olfactory epithelium, both at the cellular and the structural levels, is altered. Investigations were carried out on three experimental groups: two pathological groups (mice models with deliberately altered olfactory epithelium and Alzheimer's disease transgenic mice models) were compared with healthy mice models. As histological staining, the three tested noninvasive imaging tools demonstrated the general tubular organization of the olfactory epithelium on healthy mice. Contrary to OCT, confocal microscopy, and endomicroscopy allowed visualizing the inner structure of olfactory epithelium as well as its morphological or functional changes on pathological models, alterations classically observed with histological assessment. The results could lead to relevant development of imaging tools for noninvasive and early diagnosis of neurodegenerative diseases through the in situ characterization of the olfactory epithelium.
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spelling pubmed-73719972020-08-04 Comparison of Noninvasive Imagery Methods to Observe Healthy and Degenerated Olfactory Epithelium in Mice for the Early Diagnosis of Neurodegenerative Diseases Etievant, Adeline Monnin, Julie Lihoreau, Thomas Tamadazte, Brahim Rougeot, Patrick Magnin, Eloi Tavernier, Laurent Pazart, Lionel Haffen, Emmanuel Front Neuroanat Neuroscience Olfactory dysfunction could be an early and reliable indicator for the diagnosis of neurodegenerative disorders such as Alzheimer and Parkinson's diseases. In this paper, we compare the potential of different noninvasive medical imaging modalities (optical coherence tomography, confocal microscopy, and fluorescence endomicroscopy) to distinguish how the olfactory epithelium, both at the cellular and the structural levels, is altered. Investigations were carried out on three experimental groups: two pathological groups (mice models with deliberately altered olfactory epithelium and Alzheimer's disease transgenic mice models) were compared with healthy mice models. As histological staining, the three tested noninvasive imaging tools demonstrated the general tubular organization of the olfactory epithelium on healthy mice. Contrary to OCT, confocal microscopy, and endomicroscopy allowed visualizing the inner structure of olfactory epithelium as well as its morphological or functional changes on pathological models, alterations classically observed with histological assessment. The results could lead to relevant development of imaging tools for noninvasive and early diagnosis of neurodegenerative diseases through the in situ characterization of the olfactory epithelium. Frontiers Media S.A. 2020-07-14 /pmc/articles/PMC7371997/ /pubmed/32760253 http://dx.doi.org/10.3389/fnana.2020.00034 Text en Copyright © 2020 Etievant, Monnin, Lihoreau, Tamadazte, Rougeot, Magnin, Tavernier, Pazart and Haffen. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Etievant, Adeline
Monnin, Julie
Lihoreau, Thomas
Tamadazte, Brahim
Rougeot, Patrick
Magnin, Eloi
Tavernier, Laurent
Pazart, Lionel
Haffen, Emmanuel
Comparison of Noninvasive Imagery Methods to Observe Healthy and Degenerated Olfactory Epithelium in Mice for the Early Diagnosis of Neurodegenerative Diseases
title Comparison of Noninvasive Imagery Methods to Observe Healthy and Degenerated Olfactory Epithelium in Mice for the Early Diagnosis of Neurodegenerative Diseases
title_full Comparison of Noninvasive Imagery Methods to Observe Healthy and Degenerated Olfactory Epithelium in Mice for the Early Diagnosis of Neurodegenerative Diseases
title_fullStr Comparison of Noninvasive Imagery Methods to Observe Healthy and Degenerated Olfactory Epithelium in Mice for the Early Diagnosis of Neurodegenerative Diseases
title_full_unstemmed Comparison of Noninvasive Imagery Methods to Observe Healthy and Degenerated Olfactory Epithelium in Mice for the Early Diagnosis of Neurodegenerative Diseases
title_short Comparison of Noninvasive Imagery Methods to Observe Healthy and Degenerated Olfactory Epithelium in Mice for the Early Diagnosis of Neurodegenerative Diseases
title_sort comparison of noninvasive imagery methods to observe healthy and degenerated olfactory epithelium in mice for the early diagnosis of neurodegenerative diseases
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7371997/
https://www.ncbi.nlm.nih.gov/pubmed/32760253
http://dx.doi.org/10.3389/fnana.2020.00034
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