Acute Hyperglycemia and Spatial Working Memory in Adolescents With Type 1 Diabetes

OBJECTIVE: To investigate the effect of acute hyperglycemia on brain function in adolescents with type 1 diabetes (T1D). RESEARCH DESIGN AND METHODS: Twenty participants with T1D (aged 14.64 ± 1.78 years) and 20 age-matched healthy control subjects (aged 14.40 ± 2.82 years) performed two functional...

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Detalles Bibliográficos
Autores principales: Šuput Omladič, Jasna, Slana Ozimič, Anka, Vovk, Andrej, Šuput, Dušan, Repovš, Grega, Dovc, Klemen, Bratina, Nataša, Avbelj Stefanija, Magdalena, Battelino, Tadej
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2020
Materias:
Novel Communications in Diabetes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7372055/
https://www.ncbi.nlm.nih.gov/pubmed/32471909
http://dx.doi.org/10.2337/dc20-0171
Descripción
Sumario:OBJECTIVE: To investigate the effect of acute hyperglycemia on brain function in adolescents with type 1 diabetes (T1D). RESEARCH DESIGN AND METHODS: Twenty participants with T1D (aged 14.64 ± 1.78 years) and 20 age-matched healthy control subjects (aged 14.40 ± 2.82 years) performed two functional MRI sessions. Participants with T1D performed the first scanning session under euglycemic and the second under hyperglycemic clamp (20 mmol/L [360 mg/dL]). RESULTS: Lower spatial working memory (sWM) capacity during acute hyperglycemia and significant differences in activation of regions of interest during different stages of the sWM task (P = 0.014) were observed. CONCLUSIONS: Acute hyperglycemia negatively affected sWM capacity in adolescents with T1D, which is relevant for daily functioning and academic performance.

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