Acute Hyperglycemia and Spatial Working Memory in Adolescents With Type 1 Diabetes

OBJECTIVE: To investigate the effect of acute hyperglycemia on brain function in adolescents with type 1 diabetes (T1D). RESEARCH DESIGN AND METHODS: Twenty participants with T1D (aged 14.64 ± 1.78 years) and 20 age-matched healthy control subjects (aged 14.40 ± 2.82 years) performed two functional...

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Autores principales: Šuput Omladič, Jasna, Slana Ozimič, Anka, Vovk, Andrej, Šuput, Dušan, Repovš, Grega, Dovc, Klemen, Bratina, Nataša, Avbelj Stefanija, Magdalena, Battelino, Tadej
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2020
Materias:
Novel Communications in Diabetes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7372055/
https://www.ncbi.nlm.nih.gov/pubmed/32471909
http://dx.doi.org/10.2337/dc20-0171
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author Šuput Omladič, Jasna
Slana Ozimič, Anka
Vovk, Andrej
Šuput, Dušan
Repovš, Grega
Dovc, Klemen
Bratina, Nataša
Avbelj Stefanija, Magdalena
Battelino, Tadej
author_facet Šuput Omladič, Jasna
Slana Ozimič, Anka
Vovk, Andrej
Šuput, Dušan
Repovš, Grega
Dovc, Klemen
Bratina, Nataša
Avbelj Stefanija, Magdalena
Battelino, Tadej
author_sort Šuput Omladič, Jasna
collection PubMed
description OBJECTIVE: To investigate the effect of acute hyperglycemia on brain function in adolescents with type 1 diabetes (T1D). RESEARCH DESIGN AND METHODS: Twenty participants with T1D (aged 14.64 ± 1.78 years) and 20 age-matched healthy control subjects (aged 14.40 ± 2.82 years) performed two functional MRI sessions. Participants with T1D performed the first scanning session under euglycemic and the second under hyperglycemic clamp (20 mmol/L [360 mg/dL]). RESULTS: Lower spatial working memory (sWM) capacity during acute hyperglycemia and significant differences in activation of regions of interest during different stages of the sWM task (P = 0.014) were observed. CONCLUSIONS: Acute hyperglycemia negatively affected sWM capacity in adolescents with T1D, which is relevant for daily functioning and academic performance.
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spelling pubmed-73720552020-07-24 Acute Hyperglycemia and Spatial Working Memory in Adolescents With Type 1 Diabetes Šuput Omladič, Jasna Slana Ozimič, Anka Vovk, Andrej Šuput, Dušan Repovš, Grega Dovc, Klemen Bratina, Nataša Avbelj Stefanija, Magdalena Battelino, Tadej Diabetes Care Novel Communications in Diabetes OBJECTIVE: To investigate the effect of acute hyperglycemia on brain function in adolescents with type 1 diabetes (T1D). RESEARCH DESIGN AND METHODS: Twenty participants with T1D (aged 14.64 ± 1.78 years) and 20 age-matched healthy control subjects (aged 14.40 ± 2.82 years) performed two functional MRI sessions. Participants with T1D performed the first scanning session under euglycemic and the second under hyperglycemic clamp (20 mmol/L [360 mg/dL]). RESULTS: Lower spatial working memory (sWM) capacity during acute hyperglycemia and significant differences in activation of regions of interest during different stages of the sWM task (P = 0.014) were observed. CONCLUSIONS: Acute hyperglycemia negatively affected sWM capacity in adolescents with T1D, which is relevant for daily functioning and academic performance. American Diabetes Association 2020-08 2020-05-29 /pmc/articles/PMC7372055/ /pubmed/32471909 http://dx.doi.org/10.2337/dc20-0171 Text en © 2020 by the American Diabetes Association https://www.diabetesjournals.org/content/licenseReaders may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. More information is available at https://www.diabetesjournals.org/content/license.
spellingShingle Novel Communications in Diabetes
Šuput Omladič, Jasna
Slana Ozimič, Anka
Vovk, Andrej
Šuput, Dušan
Repovš, Grega
Dovc, Klemen
Bratina, Nataša
Avbelj Stefanija, Magdalena
Battelino, Tadej
Acute Hyperglycemia and Spatial Working Memory in Adolescents With Type 1 Diabetes
title Acute Hyperglycemia and Spatial Working Memory in Adolescents With Type 1 Diabetes
title_full Acute Hyperglycemia and Spatial Working Memory in Adolescents With Type 1 Diabetes
title_fullStr Acute Hyperglycemia and Spatial Working Memory in Adolescents With Type 1 Diabetes
title_full_unstemmed Acute Hyperglycemia and Spatial Working Memory in Adolescents With Type 1 Diabetes
title_short Acute Hyperglycemia and Spatial Working Memory in Adolescents With Type 1 Diabetes
title_sort acute hyperglycemia and spatial working memory in adolescents with type 1 diabetes
topic Novel Communications in Diabetes
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7372055/
https://www.ncbi.nlm.nih.gov/pubmed/32471909
http://dx.doi.org/10.2337/dc20-0171
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