Pds5A and Pds5B Display Non-redundant Functions in Mitosis and Their Loss Triggers Chk1 Activation

BACKGROUND: Pds5 is an abundant HEAT-repeat-containing protein that binds to cohesin and mediates sister chromatid cohesion. In vertebrates, Pds5A and Pds5B are known to protect DNA replication fork, as their loss leads to DNA damage. Pds5 interacts directly with Wapl, to remove cohesin during mitos...

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Detalles Bibliográficos
Autores principales: Al-Jomah, Naif, Mukololo, Lubinda, Anjum, Awais, Al Madadha, Mohammed, Patel, Raj
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7372117/
https://www.ncbi.nlm.nih.gov/pubmed/32760717
http://dx.doi.org/10.3389/fcell.2020.00531

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7372117/
https://www.ncbi.nlm.nih.gov/pubmed/32760717
http://dx.doi.org/10.3389/fcell.2020.00531

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