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Targeting succinate dehydrogenase with malonate ester prodrugs decreases renal ischemia reperfusion injury
Renal ischemia reperfusion (IR) injury leads to significant patient morbidity and mortality, and its amelioration is an urgent unmet clinical need. Succinate accumulates during ischemia and its oxidation by the mitochondrial enzyme succinate dehydrogenase (SDH) drives the ROS production that underli...
Autores principales: | Beach, Timothy E., Prag, Hiran A., Pala, Laura, Logan, Angela, Huang, Margaret M., Gruszczyk, Anja V., Martin, Jack L., Mahbubani, Krishnaa, Hamed, Mazin O., Hosgood, Sarah A., Nicholson, Michael L., James, Andrew M., Hartley, Richard C., Murphy, Michael P., Saeb-Parsy, Kourosh |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7372157/ https://www.ncbi.nlm.nih.gov/pubmed/32863205 http://dx.doi.org/10.1016/j.redox.2020.101640 |
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