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Treatment-Free Remission in Chronic Idiopathic Thrombocytopenic Purpura

Idiopathic thrombocytopenic purpura (ITP) is a disease in which the immune system attacks platelets and causes a decrease in their number, exposing the patient to bleeding risk. It is a diagnosis by exclusion. ITP usually presents as acute disease and is self-limiting in pediatric patients, while it...

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Autores principales: Ahmed, Mohanad, Yassin, Mohamed A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7372184/
https://www.ncbi.nlm.nih.gov/pubmed/32699701
http://dx.doi.org/10.7759/cureus.8705
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author Ahmed, Mohanad
Yassin, Mohamed A
author_facet Ahmed, Mohanad
Yassin, Mohamed A
author_sort Ahmed, Mohanad
collection PubMed
description Idiopathic thrombocytopenic purpura (ITP) is a disease in which the immune system attacks platelets and causes a decrease in their number, exposing the patient to bleeding risk. It is a diagnosis by exclusion. ITP usually presents as acute disease and is self-limiting in pediatric patients, while it tends to be chronic in adults. Eltrombopag is a thrombopoietin receptor agonist used as a second-line treatment for ITP. This drug is approved for use in adults as second-line therapy, but little is known about its use in the pediatric patient population. We report the case of a 14-year-old girl with chronic steroid-dependent ITP who responded well to eltrombopag and maintained treatment-free remission after stopping the drug.
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spelling pubmed-73721842020-07-21 Treatment-Free Remission in Chronic Idiopathic Thrombocytopenic Purpura Ahmed, Mohanad Yassin, Mohamed A Cureus Internal Medicine Idiopathic thrombocytopenic purpura (ITP) is a disease in which the immune system attacks platelets and causes a decrease in their number, exposing the patient to bleeding risk. It is a diagnosis by exclusion. ITP usually presents as acute disease and is self-limiting in pediatric patients, while it tends to be chronic in adults. Eltrombopag is a thrombopoietin receptor agonist used as a second-line treatment for ITP. This drug is approved for use in adults as second-line therapy, but little is known about its use in the pediatric patient population. We report the case of a 14-year-old girl with chronic steroid-dependent ITP who responded well to eltrombopag and maintained treatment-free remission after stopping the drug. Cureus 2020-06-19 /pmc/articles/PMC7372184/ /pubmed/32699701 http://dx.doi.org/10.7759/cureus.8705 Text en Copyright © 2020, Ahmed et al. http://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Internal Medicine
Ahmed, Mohanad
Yassin, Mohamed A
Treatment-Free Remission in Chronic Idiopathic Thrombocytopenic Purpura
title Treatment-Free Remission in Chronic Idiopathic Thrombocytopenic Purpura
title_full Treatment-Free Remission in Chronic Idiopathic Thrombocytopenic Purpura
title_fullStr Treatment-Free Remission in Chronic Idiopathic Thrombocytopenic Purpura
title_full_unstemmed Treatment-Free Remission in Chronic Idiopathic Thrombocytopenic Purpura
title_short Treatment-Free Remission in Chronic Idiopathic Thrombocytopenic Purpura
title_sort treatment-free remission in chronic idiopathic thrombocytopenic purpura
topic Internal Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7372184/
https://www.ncbi.nlm.nih.gov/pubmed/32699701
http://dx.doi.org/10.7759/cureus.8705
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