Mice Deficient in T-bet Form Inducible NO Synthase–Positive Granulomas That Fail to Constrain Salmonella

Clearance of intracellular infections caused by Salmonella Typhimurium (STm) requires IFN-γ and the Th1-associated transcription factor T-bet. Nevertheless, whereas IFN-γ(−/−) mice succumb rapidly to STm infections, T-bet(−/−) mice do not. In this study, we assess the anatomy of immune responses and...

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Detalles Bibliográficos
Autores principales: Perez-Toledo, Marisol, Beristain-Covarrubias, Nonantzin, Channell, William M., Hitchcock, Jessica R., Cook, Charlotte N., Coughlan, Ruth E., Bobat, Saeeda, Jones, Nicholas D., Nakamura, Kyoko, Ross, Ewan A., Rossiter, Amanda E., Rooke, Jessica, Garcia-Gimenez, Alicia, Jossi, Sian, Persaud, Ruby R., Marcial-Juarez, Edith, Flores-Langarica, Adriana, Henderson, Ian R., Withers, David R., Watson, Steve P., Cunningham, Adam F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AAI 2020
Materias:
Infectious Disease and Host Response
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7372318/
https://www.ncbi.nlm.nih.gov/pubmed/32591391
http://dx.doi.org/10.4049/jimmunol.2000089

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