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Antimicrobial Activity of Hybrid Nanomaterials Based on Star and Linear Polymers of N,N′-Dimethylaminoethyl Methacrylate with In Situ Produced Silver Nanoparticles

Well-defined linear and multi-arm star polymer structures were used as the templates for in situ synthesis and stabilization of silver nanoparticles (AgNPs). This approach led to hybrid nanomaterials with high stability and antibacterial activity to both Gram-positive and Gram-negative bacterial str...

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Autores principales: Teper, Paulina, Sotirova, Anna, Mitova, Violeta, Oleszko-Torbus, Natalia, Utrata-Wesołek, Alicja, Koseva, Neli, Kowalczuk, Agnieszka, Mendrek, Barbara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7372353/
https://www.ncbi.nlm.nih.gov/pubmed/32645957
http://dx.doi.org/10.3390/ma13133037
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author Teper, Paulina
Sotirova, Anna
Mitova, Violeta
Oleszko-Torbus, Natalia
Utrata-Wesołek, Alicja
Koseva, Neli
Kowalczuk, Agnieszka
Mendrek, Barbara
author_facet Teper, Paulina
Sotirova, Anna
Mitova, Violeta
Oleszko-Torbus, Natalia
Utrata-Wesołek, Alicja
Koseva, Neli
Kowalczuk, Agnieszka
Mendrek, Barbara
author_sort Teper, Paulina
collection PubMed
description Well-defined linear and multi-arm star polymer structures were used as the templates for in situ synthesis and stabilization of silver nanoparticles (AgNPs). This approach led to hybrid nanomaterials with high stability and antibacterial activity to both Gram-positive and Gram-negative bacterial strains. The ecologically friendly so called “green” synthesis of nanomaterials was performed through AgNPs preparation in the aqueous solutions of star and linear poly(N,N′-dimethylaminoethyl methacrylate)s (PDMAEMAs); the process was followed with time. The size, shape, and zeta potential of the obtained hybrids were determined. To our knowledge, this is the first time that the antibacterial activity of PDMAEMA hybrid nanomaterial against Bacillus subtilis, Escherichia coli and Pseudomonas aeruginosa was investigated and assessed by minimum inhibitory concentration (MIC) and minimum biocidal concentration (MBC). Completely quaternized with ethyl bromide, star and linear PDMAEMAs were used in comparative biological tests. The modification of the polymers with in situ-formed AgNPs increased the antibacterial properties against all studied strains of bacteria by several times in comparison to non-modified polymers and quaternized polymers. These results yield novel nanohybrid materials that can be useful for applications in medicine and biology.
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spelling pubmed-73723532020-08-05 Antimicrobial Activity of Hybrid Nanomaterials Based on Star and Linear Polymers of N,N′-Dimethylaminoethyl Methacrylate with In Situ Produced Silver Nanoparticles Teper, Paulina Sotirova, Anna Mitova, Violeta Oleszko-Torbus, Natalia Utrata-Wesołek, Alicja Koseva, Neli Kowalczuk, Agnieszka Mendrek, Barbara Materials (Basel) Article Well-defined linear and multi-arm star polymer structures were used as the templates for in situ synthesis and stabilization of silver nanoparticles (AgNPs). This approach led to hybrid nanomaterials with high stability and antibacterial activity to both Gram-positive and Gram-negative bacterial strains. The ecologically friendly so called “green” synthesis of nanomaterials was performed through AgNPs preparation in the aqueous solutions of star and linear poly(N,N′-dimethylaminoethyl methacrylate)s (PDMAEMAs); the process was followed with time. The size, shape, and zeta potential of the obtained hybrids were determined. To our knowledge, this is the first time that the antibacterial activity of PDMAEMA hybrid nanomaterial against Bacillus subtilis, Escherichia coli and Pseudomonas aeruginosa was investigated and assessed by minimum inhibitory concentration (MIC) and minimum biocidal concentration (MBC). Completely quaternized with ethyl bromide, star and linear PDMAEMAs were used in comparative biological tests. The modification of the polymers with in situ-formed AgNPs increased the antibacterial properties against all studied strains of bacteria by several times in comparison to non-modified polymers and quaternized polymers. These results yield novel nanohybrid materials that can be useful for applications in medicine and biology. MDPI 2020-07-07 /pmc/articles/PMC7372353/ /pubmed/32645957 http://dx.doi.org/10.3390/ma13133037 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Teper, Paulina
Sotirova, Anna
Mitova, Violeta
Oleszko-Torbus, Natalia
Utrata-Wesołek, Alicja
Koseva, Neli
Kowalczuk, Agnieszka
Mendrek, Barbara
Antimicrobial Activity of Hybrid Nanomaterials Based on Star and Linear Polymers of N,N′-Dimethylaminoethyl Methacrylate with In Situ Produced Silver Nanoparticles
title Antimicrobial Activity of Hybrid Nanomaterials Based on Star and Linear Polymers of N,N′-Dimethylaminoethyl Methacrylate with In Situ Produced Silver Nanoparticles
title_full Antimicrobial Activity of Hybrid Nanomaterials Based on Star and Linear Polymers of N,N′-Dimethylaminoethyl Methacrylate with In Situ Produced Silver Nanoparticles
title_fullStr Antimicrobial Activity of Hybrid Nanomaterials Based on Star and Linear Polymers of N,N′-Dimethylaminoethyl Methacrylate with In Situ Produced Silver Nanoparticles
title_full_unstemmed Antimicrobial Activity of Hybrid Nanomaterials Based on Star and Linear Polymers of N,N′-Dimethylaminoethyl Methacrylate with In Situ Produced Silver Nanoparticles
title_short Antimicrobial Activity of Hybrid Nanomaterials Based on Star and Linear Polymers of N,N′-Dimethylaminoethyl Methacrylate with In Situ Produced Silver Nanoparticles
title_sort antimicrobial activity of hybrid nanomaterials based on star and linear polymers of n,n′-dimethylaminoethyl methacrylate with in situ produced silver nanoparticles
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7372353/
https://www.ncbi.nlm.nih.gov/pubmed/32645957
http://dx.doi.org/10.3390/ma13133037
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