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Bioenergetic deficits in Huntington’s disease iPSC-derived neural cells and rescue with glycolytic metabolites
Altered cellular metabolism is believed to be an important contributor to pathogenesis of the neurodegenerative disorder Huntington’s disease (HD). Research has primarily focused on mitochondrial toxicity, which can cause death of the vulnerable striatal neurons, but other aspects of metabolism have...
| Formato: | Online Artículo Texto |
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| Lenguaje: | English |
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Oxford University Press
2020
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7372552/ https://www.ncbi.nlm.nih.gov/pubmed/30768179 http://dx.doi.org/10.1093/hmg/ddy430 |