Asymmetric Total Synthesis of Mycobacterial Diacyl Trehaloses Demonstrates a Role for Lipid Structure in Immunogenicity

[Image: see text] The first asymmetric total synthesis of three structures proposed for mycobacterial diacyl trehaloses, DAT(1), DAT(2), and DAT(3) is reported. The presence of two of these glycolipids, DAT(1) and DAT(3), within different strains of pathogenic M. tuberculosis was confirmed, and it w...

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Detalles Bibliográficos
Autores principales: Holzheimer, Mira, Reijneveld, Josephine F., Ramnarine, Alexandrea K., Misiakos, Georgios, Young, David C., Ishikawa, Eri, Cheng, Tan-Yun, Yamasaki, Sho, Moody, D. Branch, Van Rhijn, Ildiko, Minnaard, Adriaan J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2020
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7372558/
https://www.ncbi.nlm.nih.gov/pubmed/32293864
http://dx.doi.org/10.1021/acschembio.0c00030

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