Cargando…

High-Content Phenotypic Profiling in Esophageal Adenocarcinoma Identifies Selectively Active Pharmacological Classes of Drugs for Repurposing and Chemical Starting Points for Novel Drug Discovery

Esophageal adenocarcinoma (EAC) is a highly heterogeneous disease, dominated by large-scale genomic rearrangements and copy number alterations. Such characteristics have hampered conventional target-directed drug discovery and personalized medicine strategies, contributing to poor outcomes for patie...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hughes, Rebecca E., Elliott, Richard J. R., Munro, Alison F., Makda, Ashraff, O’Neill, J. Robert, Hupp, Ted, Carragher, Neil O.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	SAGE Publications 2020
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7372582/ https://www.ncbi.nlm.nih.gov/pubmed/32441181 http://dx.doi.org/10.1177/2472555220917115

Ejemplares similares

Multiparametric High-Content Cell Painting Identifies Copper Ionophores as Selective Modulators of Esophageal Cancer Phenotypes
por: Hughes, Rebecca E., et al.
Publicado: (2022)

Application of a High-Content Screening Assay Utilizing Primary Human Lung Fibroblasts to Identify Antifibrotic Drugs for Rapid Repurposing in COVID-19 Patients
por: Marwick, John A., et al.
Publicado: (2021)

High content phenotypic screening identifies serotonin receptor modulators with selective activity upon breast cancer cell cycle and cytokine signaling pathways
por: Warchal, Scott J., et al.
Publicado: (2020)

Naturally Inspired Peptide Leads: Alanine Scanning Reveals an Actin‐Targeting Thiazole Analogue of Bisebromoamide
por: Johnston, Heather J., et al.
Publicado: (2016)

A Novel High-Content Phenotypic Screen To Identify Inhibitors of Mitochondrial DNA Maintenance in Trypanosomes
por: Miskinyte, Migla, et al.
Publicado: (2022)

Drug Repurposing: An Effective Tool in Modern Drug Discovery
por: Kulkarni, V. S., et al.
Publicado: (2023)

Drug repurposing: An effective strategy to accelerate contemporary drug discovery
por: Zhan, Peng, et al.
Publicado: (2022)

Advances in Antifungal Development: Discovery of New Drugs and Drug Repurposing
por: Kim, Jong H., et al.
Publicado: (2022)

Fruit fly for anticancer drug discovery and repurposing
por: Nainu, Firzan, et al.
Publicado: (2023)

Drug repurposing: a better approach for infectious disease drug discovery?
por: Law, G Lynn, et al.
Publicado: (2013)

Drug Repurposing: A New Hope in Drug Discovery for Prostate Cancer
por: Malik, Jonaid Ahmad, et al.
Publicado: (2022)

Pharmacological Efficacy of Repurposing Drugs in the Treatment of Prostate Cancer
por: Lourenço, Tânia, et al.
Publicado: (2023)

New opportunities for kinase drug repurposing and target discovery
por: Knapp, Stefan
Publicado: (2018)

Emerging target discovery and drug repurposing opportunities in chordoma
por: Freed, Daniel M., et al.
Publicado: (2022)

Drug repurposing in cardiology
por: van Driel, B. O., et al.
Publicado: (2020)

COVID-19: molecular targets, drug repurposing and new avenues for drug discovery
por: Senger, Mario Roberto, et al.
Publicado: (2020)

Discovery of new drug indications for COVID-19: A drug repurposing approach
por: Kumari, Priyanka, et al.
Publicado: (2022)

Chemical-induced gene expression ranking and its application to pancreatic cancer drug repurposing
por: Pham, Thai-Hoang, et al.
Publicado: (2022)

Toxins in Drug Discovery and Pharmacology
por: Peigneur, Steve, et al.
Publicado: (2018)

Repurposing paclitaxel for the treatment of fibrosis: indication discovery for existing drugs
por: Chen, Xiao-Wu, et al.
Publicado: (2015)

Drug repurposing: Discovery of troxipide analogs as potent antitumor agents
por: Lu, Nan, et al.
Publicado: (2020)

Strategy, Progress, and Challenges of Drug Repurposing for Efficient Antiviral Discovery
por: Li, Xinlei, et al.
Publicado: (2021)

Ex vivo drug sensitivity testing as a means for drug repurposing in esophageal adenocarcinoma
por: Lohse, Ines, et al.
Publicado: (2018)

Exploration of the Anti-Inflammatory Drug Space Through Network Pharmacology: Applications for Drug Repurposing
por: de Anda-Jáuregui, Guillermo, et al.
Publicado: (2018)

Drug Repurposing and De Novo Drug Discovery of Protein Kinase Inhibitors as New Drugs against Schistosomiasis
por: Pereira Moreira, Bernardo, et al.
Publicado: (2022)

Accelerating glioblastoma drug discovery: Convergence of patient-derived models, genome editing and phenotypic screening
por: O'Duibhir, Eoghan, et al.
Publicado: (2016)

Barbiturates and pyrazolopyridines for the treatment of postpartum depression—repurposing of two drug classes
por: Horwitz, Alexander B., et al.
Publicado: (2023)

Drug repurposing for the treatment of COVID-19: Pharmacological aspects and synthetic approaches
por: Batalha, Pedro N., et al.
Publicado: (2021)

Drug Repurposing for COVID-19 Treatment by Integrating Network Pharmacology and Transcriptomics
por: Liu, Dan-Yang, et al.
Publicado: (2021)

Use of Computational Functional Genomics in Drug Discovery and Repurposing for Analgesic Indications
por: Lötsch, Jörn, et al.
Publicado: (2018)

Repurposing A549 Adenocarcinoma Cells: New Options for Drug Discovery
por: Garcia-de-Alba, Carolina
Publicado: (2021)

Computational Drug Repurposing for Antituberculosis Therapy: Discovery of Multi-Strain Inhibitors
por: Kleandrova, Valeria V., et al.
Publicado: (2021)

Target-specific compound selectivity for multi-target drug discovery and repurposing
por: Wang, Tianduanyi, et al.
Publicado: (2022)

Resurgence and Repurposing of Antifungal Azoles by Transition Metal Coordination for Drug Discovery
por: Cortat, Youri, et al.
Publicado: (2023)

Drug Development Digital Twins for Drug Discovery, Testing and Repurposing: A Schema for Requirements and Development
por: An, Gary, et al.
Publicado: (2022)

Editorial: Drug repurposing and polypharmacology: A synergistic approach in multi-target based drug discovery
por: Rudrapal, Mithun, et al.
Publicado: (2022)

Editorial: Biological aspects of targeted drug discovery: Development of novel targets and/or chemotherapies, and drug repurposing
por: Kalra, Rajkumar Singh, et al.
Publicado: (2022)

Antiviral Activity of Approved Antibacterial, Antifungal, Antiprotozoal and Anthelmintic Drugs: Chances for Drug Repurposing for Antiviral Drug Discovery
por: Abdulaziz, Leena, et al.
Publicado: (2022)

A platform for detecting cross-resistance in antibacterial drug discovery
por: Galarion, Luiza H, et al.
Publicado: (2021)

Systematic analyses of drugs and disease indications in RepurposeDB reveal pharmacological, biological and epidemiological factors influencing drug repositioning
por: Shameer, Khader, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_j7tggagfa25b59psirob9gu00l