Research on the Correlation of Serum PCT and Plasma GSN Levels with the Prognosis of Urosepsis Patients

OBJECTIVE: To explore the correlation of procalcitonin (PCT) and gelsolin (GSN) with the prognosis of urosepsis patients. METHOD: The data of 71 urosepsis patients from March 2015 to April 2019 who were admitted to and treated in Affiliated Hospital of Hebei University were analyzed and compared with those of 92 healthy persons. Serum PCT and plasma GSN levels at different times after treatment were detected. According to prognosis, patients were classified into the good prognosis group or the poor prognosis group. The serum PCT and plasma GSN levels of both groups were compared. RESULT: The serum PCT level of the urosepsis group on the 1(st), 3(rd), 5(th) and 7(th) days was obviously higher than that of the control group (P<0.05). The plasma GSN levels of the urosepsis group on the 1(st), 3(rd), 5(th) and 7(th) days were obviously lower than those of the control group (P<0.05). The serum PCT level of the poor prognosis group on the 1(st), 3(rd), 5(th) and 7(th) days was obviously higher than that of the good prognosis group (P<0.05). The plasma GSN level of the poor prognosis group on the 1(st), 3(rd), 5(th) and 7(th) days was obviously lower than that of the good prognosis group (P<0.05). PCT was an independent risk factor influencing the prognosis of urosepsis patients and that GSN was a protective factor (P<0.05). CONCLUSION: The serum PCT and plasma GSN levels can accurately predict the severity and prognosis of urosepsis patients and reflect the disease state of early urosepsis patients. High PCT levels and low GSN levels indicate poor prognosis, and clinicians should consider these values.