LncRNA & Wnt signaling in colorectal cancer

The outlook for new therapeutic approaches is pivotal to ameliorate the deterioration caused by the abrogated Wnt signaling. Long non-coding RNAs (lncRNAs) are tiny molecules that have begun emerging as vital molecular manager for the regulation of various cellular processes at transcription and tra...

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Autores principales: Javed, Zeeshan, Khan, Khushbukhat, Sadia, Haleema, Raza, Shahid, Salehi, Bahare, Sharifi-Rad, Javad, Cho, William C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7372757/
https://www.ncbi.nlm.nih.gov/pubmed/32699525
http://dx.doi.org/10.1186/s12935-020-01412-7
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author Javed, Zeeshan
Khan, Khushbukhat
Sadia, Haleema
Raza, Shahid
Salehi, Bahare
Sharifi-Rad, Javad
Cho, William C.
author_facet Javed, Zeeshan
Khan, Khushbukhat
Sadia, Haleema
Raza, Shahid
Salehi, Bahare
Sharifi-Rad, Javad
Cho, William C.
author_sort Javed, Zeeshan
collection PubMed
description The outlook for new therapeutic approaches is pivotal to ameliorate the deterioration caused by the abrogated Wnt signaling. Long non-coding RNAs (lncRNAs) are tiny molecules that have begun emerging as vital molecular manager for the regulation of various cellular processes at transcription and translation levels in the colorectal cancer (CRC). Targeting Wnt pathway with lncRNA seems a promising approach to eradicate CRC. However, little is known of their active role in commencing both apoptosis and proliferation in CRC. This article  reviews the importance of these molecules in the pathogenesis of CRC and also emphasizes on the development of new therapeutic strategies to cope with the Wnt mediated CRC.
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spelling pubmed-73727572020-07-21 LncRNA & Wnt signaling in colorectal cancer Javed, Zeeshan Khan, Khushbukhat Sadia, Haleema Raza, Shahid Salehi, Bahare Sharifi-Rad, Javad Cho, William C. Cancer Cell Int Review The outlook for new therapeutic approaches is pivotal to ameliorate the deterioration caused by the abrogated Wnt signaling. Long non-coding RNAs (lncRNAs) are tiny molecules that have begun emerging as vital molecular manager for the regulation of various cellular processes at transcription and translation levels in the colorectal cancer (CRC). Targeting Wnt pathway with lncRNA seems a promising approach to eradicate CRC. However, little is known of their active role in commencing both apoptosis and proliferation in CRC. This article  reviews the importance of these molecules in the pathogenesis of CRC and also emphasizes on the development of new therapeutic strategies to cope with the Wnt mediated CRC. BioMed Central 2020-07-20 /pmc/articles/PMC7372757/ /pubmed/32699525 http://dx.doi.org/10.1186/s12935-020-01412-7 Text en © The Author(s) 2020 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Javed, Zeeshan
Khan, Khushbukhat
Sadia, Haleema
Raza, Shahid
Salehi, Bahare
Sharifi-Rad, Javad
Cho, William C.
LncRNA & Wnt signaling in colorectal cancer
title LncRNA & Wnt signaling in colorectal cancer
title_full LncRNA & Wnt signaling in colorectal cancer
title_fullStr LncRNA & Wnt signaling in colorectal cancer
title_full_unstemmed LncRNA & Wnt signaling in colorectal cancer
title_short LncRNA & Wnt signaling in colorectal cancer
title_sort lncrna & wnt signaling in colorectal cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7372757/
https://www.ncbi.nlm.nih.gov/pubmed/32699525
http://dx.doi.org/10.1186/s12935-020-01412-7
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AT salehibahare lncrnawntsignalingincolorectalcancer
AT sharifiradjavad lncrnawntsignalingincolorectalcancer
AT chowilliamc lncrnawntsignalingincolorectalcancer

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