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Antiproliferative and photoprotective activities of the extracts and compounds from Calea fruticosa
In this paper, we complement our previous study on the antiproliferative activity of Calea fruticosa (Asteraceae) by isolating the compounds apigenin-4',7-dimethyl ether (1), budlein A (2), quercetin (3), and cichoriin (4) from the plant’s aerial parts. The antiproliferative activity of these c...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Associação Brasileira de Divulgação Científica
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7372941/ https://www.ncbi.nlm.nih.gov/pubmed/32696817 http://dx.doi.org/10.1590/1414-431X20209375 |
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author | Seregheti, T.M.Q. Pinto, A.P.R. Gonçalves, M.da C. Antunes, A.dos S. Almeida, W.A.da S. Machado, R.S. Silva, J.N. Ferreira, P.M.P. Pessoa, C. dos Santos, V.M.R. do Nascimento, A.M. |
author_facet | Seregheti, T.M.Q. Pinto, A.P.R. Gonçalves, M.da C. Antunes, A.dos S. Almeida, W.A.da S. Machado, R.S. Silva, J.N. Ferreira, P.M.P. Pessoa, C. dos Santos, V.M.R. do Nascimento, A.M. |
author_sort | Seregheti, T.M.Q. |
collection | PubMed |
description | In this paper, we complement our previous study on the antiproliferative activity of Calea fruticosa (Asteraceae) by isolating the compounds apigenin-4',7-dimethyl ether (1), budlein A (2), quercetin (3), and cichoriin (4) from the plant’s aerial parts. The antiproliferative activity of these compounds was evaluated by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) method against human tumor cell lines. Compound 3 displayed moderate antiproliferative activity in three cell lines (HCT-116, PC-3, and SF-295, with cell growth inhibition values of 72.97, 74.55, and 68.94%) and high antiproliferative activity (90.86%) in the HL-60 cell line. The in vitro sun protection factor (SPF) of the extracts and compound 4, with and without sunscreen, was determined by a spectrophotometric method. The ethanol extract exhibited the highest SPF (9.67) at a concentration of 0.100 mg/mL, while compound 4, isolated from this extract, showed a SPF of 13.79 at the same concentration. A relative increased efficacy of SPF was observed for the extracts and compound 4 when sunscreen was also used. Compound 4 has not been reported previously from any species within the genus Calea. Compounds 1–4 were obtained from this species for the first time. |
format | Online Article Text |
id | pubmed-7372941 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Associação Brasileira de Divulgação Científica |
record_format | MEDLINE/PubMed |
spelling | pubmed-73729412020-07-29 Antiproliferative and photoprotective activities of the extracts and compounds from Calea fruticosa Seregheti, T.M.Q. Pinto, A.P.R. Gonçalves, M.da C. Antunes, A.dos S. Almeida, W.A.da S. Machado, R.S. Silva, J.N. Ferreira, P.M.P. Pessoa, C. dos Santos, V.M.R. do Nascimento, A.M. Braz J Med Biol Res Research Article In this paper, we complement our previous study on the antiproliferative activity of Calea fruticosa (Asteraceae) by isolating the compounds apigenin-4',7-dimethyl ether (1), budlein A (2), quercetin (3), and cichoriin (4) from the plant’s aerial parts. The antiproliferative activity of these compounds was evaluated by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) method against human tumor cell lines. Compound 3 displayed moderate antiproliferative activity in three cell lines (HCT-116, PC-3, and SF-295, with cell growth inhibition values of 72.97, 74.55, and 68.94%) and high antiproliferative activity (90.86%) in the HL-60 cell line. The in vitro sun protection factor (SPF) of the extracts and compound 4, with and without sunscreen, was determined by a spectrophotometric method. The ethanol extract exhibited the highest SPF (9.67) at a concentration of 0.100 mg/mL, while compound 4, isolated from this extract, showed a SPF of 13.79 at the same concentration. A relative increased efficacy of SPF was observed for the extracts and compound 4 when sunscreen was also used. Compound 4 has not been reported previously from any species within the genus Calea. Compounds 1–4 were obtained from this species for the first time. Associação Brasileira de Divulgação Científica 2020-07-17 /pmc/articles/PMC7372941/ /pubmed/32696817 http://dx.doi.org/10.1590/1414-431X20209375 Text en https://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Seregheti, T.M.Q. Pinto, A.P.R. Gonçalves, M.da C. Antunes, A.dos S. Almeida, W.A.da S. Machado, R.S. Silva, J.N. Ferreira, P.M.P. Pessoa, C. dos Santos, V.M.R. do Nascimento, A.M. Antiproliferative and photoprotective activities of the extracts and compounds from Calea fruticosa |
title | Antiproliferative and photoprotective activities of the extracts and
compounds from Calea fruticosa
|
title_full | Antiproliferative and photoprotective activities of the extracts and
compounds from Calea fruticosa
|
title_fullStr | Antiproliferative and photoprotective activities of the extracts and
compounds from Calea fruticosa
|
title_full_unstemmed | Antiproliferative and photoprotective activities of the extracts and
compounds from Calea fruticosa
|
title_short | Antiproliferative and photoprotective activities of the extracts and
compounds from Calea fruticosa
|
title_sort | antiproliferative and photoprotective activities of the extracts and
compounds from calea fruticosa |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7372941/ https://www.ncbi.nlm.nih.gov/pubmed/32696817 http://dx.doi.org/10.1590/1414-431X20209375 |
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