Cargando…
Precision multiparameter tracking of inflammation on timescales of hours to years using serial dried blood spots
Aim: High-frequency longitudinal tracking of inflammation using dried blood microsamples provides a new window for personalized monitoring of infections, chronic inflammatory disease and clinical trials of anti-inflammatory drugs. Results/methodology: Using 1662 dried blood spot samples collected by...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Newlands Press Ltd
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7372997/ https://www.ncbi.nlm.nih.gov/pubmed/32253915 http://dx.doi.org/10.4155/bio-2019-0278 |
_version_ | 1783561420912197632 |
---|---|
author | Anderson, Leigh Razavi, Morteza Pope, Matthew E Yip, Richard Cameron, LC Bassini-Cameron, Adriana Pearson, Terry W |
author_facet | Anderson, Leigh Razavi, Morteza Pope, Matthew E Yip, Richard Cameron, LC Bassini-Cameron, Adriana Pearson, Terry W |
author_sort | Anderson, Leigh |
collection | PubMed |
description | Aim: High-frequency longitudinal tracking of inflammation using dried blood microsamples provides a new window for personalized monitoring of infections, chronic inflammatory disease and clinical trials of anti-inflammatory drugs. Results/methodology: Using 1662 dried blood spot samples collected by 16 subjects over periods of weeks to years, we studied the behavior of 12 acute phase response and related proteins in inflammation events correlated with infection, vaccination, surgery, intense exercise and Crohn's disease. Proteins were measured using SISCAPA mass spectrometry and normalized to constant plasma volume using low-variance proteins, generating high precision within-person biomarker trajectories with well-characterized personal baselines. Discussion/conclusion: The results shed new light on the dynamic regulation of APR responses, offering a new approach to visualization of multidimensional inflammation trajectories. |
format | Online Article Text |
id | pubmed-7372997 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Newlands Press Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-73729972020-07-21 Precision multiparameter tracking of inflammation on timescales of hours to years using serial dried blood spots Anderson, Leigh Razavi, Morteza Pope, Matthew E Yip, Richard Cameron, LC Bassini-Cameron, Adriana Pearson, Terry W Bioanalysis Research Article Aim: High-frequency longitudinal tracking of inflammation using dried blood microsamples provides a new window for personalized monitoring of infections, chronic inflammatory disease and clinical trials of anti-inflammatory drugs. Results/methodology: Using 1662 dried blood spot samples collected by 16 subjects over periods of weeks to years, we studied the behavior of 12 acute phase response and related proteins in inflammation events correlated with infection, vaccination, surgery, intense exercise and Crohn's disease. Proteins were measured using SISCAPA mass spectrometry and normalized to constant plasma volume using low-variance proteins, generating high precision within-person biomarker trajectories with well-characterized personal baselines. Discussion/conclusion: The results shed new light on the dynamic regulation of APR responses, offering a new approach to visualization of multidimensional inflammation trajectories. Newlands Press Ltd 2020-04-07 2020-03 /pmc/articles/PMC7372997/ /pubmed/32253915 http://dx.doi.org/10.4155/bio-2019-0278 Text en © 2020 Newlands Press This work is licensed under the Creative Commons Attribution 4.0 License (http://creativecommons.org/licenses/by/4.0/) |
spellingShingle | Research Article Anderson, Leigh Razavi, Morteza Pope, Matthew E Yip, Richard Cameron, LC Bassini-Cameron, Adriana Pearson, Terry W Precision multiparameter tracking of inflammation on timescales of hours to years using serial dried blood spots |
title | Precision multiparameter tracking of inflammation on timescales of hours to years using serial dried blood spots |
title_full | Precision multiparameter tracking of inflammation on timescales of hours to years using serial dried blood spots |
title_fullStr | Precision multiparameter tracking of inflammation on timescales of hours to years using serial dried blood spots |
title_full_unstemmed | Precision multiparameter tracking of inflammation on timescales of hours to years using serial dried blood spots |
title_short | Precision multiparameter tracking of inflammation on timescales of hours to years using serial dried blood spots |
title_sort | precision multiparameter tracking of inflammation on timescales of hours to years using serial dried blood spots |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7372997/ https://www.ncbi.nlm.nih.gov/pubmed/32253915 http://dx.doi.org/10.4155/bio-2019-0278 |
work_keys_str_mv | AT andersonleigh precisionmultiparametertrackingofinflammationontimescalesofhourstoyearsusingserialdriedbloodspots AT razavimorteza precisionmultiparametertrackingofinflammationontimescalesofhourstoyearsusingserialdriedbloodspots AT popematthewe precisionmultiparametertrackingofinflammationontimescalesofhourstoyearsusingserialdriedbloodspots AT yiprichard precisionmultiparametertrackingofinflammationontimescalesofhourstoyearsusingserialdriedbloodspots AT cameronlc precisionmultiparametertrackingofinflammationontimescalesofhourstoyearsusingserialdriedbloodspots AT bassinicameronadriana precisionmultiparametertrackingofinflammationontimescalesofhourstoyearsusingserialdriedbloodspots AT pearsonterryw precisionmultiparametertrackingofinflammationontimescalesofhourstoyearsusingserialdriedbloodspots |