Heparan sulfate assists SARS-CoV-2 in cell entry and can be targeted by approved drugs in vitro

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The cell entry of SARS-CoV-2 has emerged as an attractive drug repurposing target for COVID-19. Here we combine genetics and chemical perturbation to demonstrate that ACE2-mediated entry of SARS-CoV and CoV-2 requires the cell surface heparan sulfate (HS) as an assisting cofactor: ablation of genes...

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Detalles Bibliográficos
Autores principales: Zhang, Qi, Chen, Catherine Z., Swaroop, Manju, Xu, Miao, Wang, Lihui, Lee, Juhyung, Wang, Amy Q., Pradhan, Manisha, Hagen, Natalie, Chen, Lu, Shen, Min, Luo, Zhiji, Xu, Xin, Xu, Yue, Huang, Wenwei, Zheng, Wei, Ye, Yihong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7373127/
https://www.ncbi.nlm.nih.gov/pubmed/32699847
http://dx.doi.org/10.1101/2020.07.14.202549

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