Cargando…

New insights on human essential genes based on integrated analysis and the construction of the HEGIAP web-based platform

Essential genes are those whose loss of function compromises organism viability or results in profound loss of fitness. Recent gene-editing technologies have provided new opportunities to characterize essential genes. Here, we present an integrated analysis that comprehensively and systematically el...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chen, Hebing, Zhang, Zhuo, Jiang, Shuai, Li, Ruijiang, Li, Wanying, Zhao, Chenghui, Hong, Hao, Huang, Xin, Li, Hao, Bo, Xiaochen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2019
Materias:	Problem Solving Protocol
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7373178/ https://www.ncbi.nlm.nih.gov/pubmed/31504171 http://dx.doi.org/10.1093/bib/bbz072

Ejemplares similares

Spatial density of open chromatin: an effective metric for the functional characterization of topologically associated domains
por: Jiang, Shuai, et al.
Publicado: (2020)

FireProt 2.0: web-based platform for the fully automated design of thermostable proteins
por: Musil, Milos, et al.
Publicado: (2023)

McAN: a novel computational algorithm and platform for constructing and visualizing haplotype networks
por: Li, Lun, et al.
Publicado: (2023)

e-TSN: an interactive visual exploration platform for target–disease knowledge mapping from literature
por: Feng, Ziyan, et al.
Publicado: (2022)

Improving the performance of single-cell RNA-seq data mining based on relative expression orderings
por: Chen, Yuanyuan, et al.
Publicado: (2022)

CysModDB: a comprehensive platform with the integration of manually curated resources and analysis tools for cysteine posttranslational modifications
por: Meng, Yanzheng, et al.
Publicado: (2022)

scHiMe: predicting single-cell DNA methylation levels based on single-cell Hi-C data
por: Zhu, Hao, et al.
Publicado: (2023)

Addressing noise in co-expression network construction
por: Burns, Joshua J R, et al.
Publicado: (2021)

BML: a versatile web server for bipartite motif discovery
por: Vahed, Mohammad, et al.
Publicado: (2021)

Multiomics integration-based molecular characterizations of COVID-19
por: Li, Chuan-Xing, et al.
Publicado: (2021)

D3AI-CoV: a deep learning platform for predicting drug targets and for virtual screening against COVID-19
por: Yang, Yanqing, et al.
Publicado: (2022)

Virus-CKB: an integrated bioinformatics platform and analysis resource for COVID-19 research
por: Feng, Zhiwei, et al.
Publicado: (2020)

FireProt(ASR): A Web Server for Fully Automated Ancestral Sequence Reconstruction
por: Musil, Milos, et al.
Publicado: (2020)

cSurvival: a web resource for biomarker interactions in cancer outcomes and in cell lines
por: Cheng, Xuanjin, et al.
Publicado: (2022)

HLA3D: an integrated structure-based computational toolkit for immunotherapy
por: Li, Xingyu, et al.
Publicado: (2022)

PedMiner: a tool for linkage analysis-based identification of disease-associated variants using family based whole-exome sequencing data
por: Zhou, Jianteng, et al.
Publicado: (2020)

MeSHHeading2vec: a new method for representing MeSH headings as vectors based on graph embedding algorithm
por: Guo, Zhen-Hao, et al.
Publicado: (2020)

DLRAPom: a hybrid pipeline of Optimized XGBoost-guided integrative multiomics analysis for identifying targetable disease-related lncRNA–miRNA–mRNA regulatory axes
por: Shen, Chen, et al.
Publicado: (2022)

ASPIRER: a new computational approach for identifying non-classical secreted proteins based on deep learning
por: Wang, Xiaoyu, et al.
Publicado: (2022)

Machine learning revealed stemness features and a novel stemness-based classification with appealing implications in discriminating the prognosis, immunotherapy and temozolomide responses of 906 glioblastoma patients
por: Wang, Zihao, et al.
Publicado: (2021)

slORFfinder: a tool to detect open reading frames resulting from trans-splicing of spliced leader sequences
por: Song, Bo, et al.
Publicado: (2023)

Deep learning model reveals potential risk genes for ADHD, especially Ephrin receptor gene EPHA5
por: Liu, Lu, et al.
Publicado: (2021)

Assessing protein model quality based on deep graph coupled networks using protein language model
por: Liu, Dong, et al.
Publicado: (2023)

An inductive graph neural network model for compound–protein interaction prediction based on a homogeneous graph
por: Wan, Xiaozhe, et al.
Publicado: (2022)

A Markov random field model-based approach for differentially expressed gene detection from single-cell RNA-seq data
por: Zhu, Biqing, et al.
Publicado: (2022)

A survey and evaluation of Web-based tools/databases for variant analysis of TCGA data
por: Zhang, Zhuo, et al.
Publicado: (2018)

Deep learning based on biologically interpretable genome representation predicts two types of human adaptation of SARS-CoV-2 variants
por: Li, Jing, et al.
Publicado: (2022)

MpbPPI: a multi-task pre-training-based equivariant approach for the prediction of the effect of amino acid mutations on protein–protein interactions
por: Yue, Yang, et al.
Publicado: (2023)

DISMIR: Deep learning-based noninvasive cancer detection by integrating DNA sequence and methylation information of individual cell-free DNA reads
por: Li, Jiaqi, et al.
Publicado: (2021)

OPUS-Rota4: a gradient-based protein side-chain modeling framework assisted by deep learning-based predictors
por: Xu, Gang, et al.
Publicado: (2021)

Systematic optimization of host-directed therapeutic targets and preclinical validation of repositioned antiviral drugs
por: Xie, Dafei, et al.
Publicado: (2022)

A general optimization protocol for molecular property prediction using a deep learning network
por: Chen, Jen-Hao, et al.
Publicado: (2021)

NAMS webserver: coding potential assessment and functional annotation of plant transcripts
por: Sun, Kun, et al.
Publicado: (2020)

Network-based modeling of herb combinations in traditional Chinese medicine
por: Wang, Yinyin, et al.
Publicado: (2021)

Interaction-based transcriptome analysis via differential network inference
por: Leng, Jiacheng, et al.
Publicado: (2022)

cropCSM: designing safe and potent herbicides with graph-based signatures
por: Pires, Douglas E V, et al.
Publicado: (2022)

Quantum annealing-based clustering of single cell RNA-seq data
por: Kubacki, Michal, et al.
Publicado: (2023)

ngsComposer: an automated pipeline for empirically based NGS data quality filtering
por: Kuster, Ryan D, et al.
Publicado: (2021)

Benchmarking network-based gene prioritization methods for cerebral small vessel disease
por: Zhang, Huayu, et al.
Publicado: (2021)

RNA2HLA: HLA-based quality control of RNA-seq datasets
por: Chelysheva, Irina, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_soejp7vc2kncpft18km1lol3hj