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Therapeutic use of botulinum toxin in pain treatment

Botulinum toxin is one of the most potent molecule known to mankind. A neurotoxin, with high affinity for cholinergic synapse, is effectively capable of inhibiting the release of acetylcholine. On the other hand, botulinum toxin is therapeutically used for several musculoskeletal disorders. Although...

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Detalles Bibliográficos
Autor principal: Kumar, Raj
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7373233/
https://www.ncbi.nlm.nih.gov/pubmed/32714587
http://dx.doi.org/10.1042/NS20180058
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author Kumar, Raj
author_facet Kumar, Raj
author_sort Kumar, Raj
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description Botulinum toxin is one of the most potent molecule known to mankind. A neurotoxin, with high affinity for cholinergic synapse, is effectively capable of inhibiting the release of acetylcholine. On the other hand, botulinum toxin is therapeutically used for several musculoskeletal disorders. Although most of the therapeutic effect of botulinum toxin is due to temporary skeletal muscle relaxation (mainly due to inhibition of the acetylcholine release), other effects on the nervous system are also investigated. One of the therapeutically investigated areas of the botulinum neurotoxin (BoNT) is the treatment of pain. At present, it is used for several chronic pain diseases, such as myofascial syndrome, headaches, arthritis, and neuropathic pain. Although the effect of botulinum toxin in pain is mainly due to its effect on cholinergic transmission in the somatic and autonomic nervous systems, research suggests that botulinum toxin can also provide benefits related to effects on cholinergic control of cholinergic nociceptive and antinociceptive systems. Furthermore, evidence suggests that botulinum toxin can also affect central nervous system (CNS). In summary, botulinum toxin holds great potential for pain treatments. It may be also useful for the pain treatments where other methods are ineffective with no side effect(s). Further studies will establish the exact analgesic mechanisms, efficacy, and complication of botulinum toxin in chronic pain disorders, and to some extent acute pain disorders.
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spelling pubmed-73732332020-07-23 Therapeutic use of botulinum toxin in pain treatment Kumar, Raj Neuronal Signal Therapeutics & Molecular Medicine Botulinum toxin is one of the most potent molecule known to mankind. A neurotoxin, with high affinity for cholinergic synapse, is effectively capable of inhibiting the release of acetylcholine. On the other hand, botulinum toxin is therapeutically used for several musculoskeletal disorders. Although most of the therapeutic effect of botulinum toxin is due to temporary skeletal muscle relaxation (mainly due to inhibition of the acetylcholine release), other effects on the nervous system are also investigated. One of the therapeutically investigated areas of the botulinum neurotoxin (BoNT) is the treatment of pain. At present, it is used for several chronic pain diseases, such as myofascial syndrome, headaches, arthritis, and neuropathic pain. Although the effect of botulinum toxin in pain is mainly due to its effect on cholinergic transmission in the somatic and autonomic nervous systems, research suggests that botulinum toxin can also provide benefits related to effects on cholinergic control of cholinergic nociceptive and antinociceptive systems. Furthermore, evidence suggests that botulinum toxin can also affect central nervous system (CNS). In summary, botulinum toxin holds great potential for pain treatments. It may be also useful for the pain treatments where other methods are ineffective with no side effect(s). Further studies will establish the exact analgesic mechanisms, efficacy, and complication of botulinum toxin in chronic pain disorders, and to some extent acute pain disorders. Portland Press Ltd. 2018-08-31 /pmc/articles/PMC7373233/ /pubmed/32714587 http://dx.doi.org/10.1042/NS20180058 Text en © 2018 The Author(s). https://creativecommons.org/licenses/by/4.0/ This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY).
spellingShingle Therapeutics & Molecular Medicine
Kumar, Raj
Therapeutic use of botulinum toxin in pain treatment
title Therapeutic use of botulinum toxin in pain treatment
title_full Therapeutic use of botulinum toxin in pain treatment
title_fullStr Therapeutic use of botulinum toxin in pain treatment
title_full_unstemmed Therapeutic use of botulinum toxin in pain treatment
title_short Therapeutic use of botulinum toxin in pain treatment
title_sort therapeutic use of botulinum toxin in pain treatment
topic Therapeutics & Molecular Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7373233/
https://www.ncbi.nlm.nih.gov/pubmed/32714587
http://dx.doi.org/10.1042/NS20180058
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