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Targeting bone morphogenetic protein signalling in midbrain dopaminergic neurons as a therapeutic approach in Parkinson's disease

Parkinson's disease (PD) is the second most common neurodegenerative disease, characterized by the degeneration of midbrain dopaminergic (mDA) neurons and their axons, and aggregation of α-synuclein, which leads to motor and late-stage cognitive impairments. As the motor symptoms of PD are caus...

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Detalles Bibliográficos
Autores principales: O'Keeffe, Gerard W., Hegarty, Shane V., Sullivan, Aideen M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7373244/
https://www.ncbi.nlm.nih.gov/pubmed/32714578
http://dx.doi.org/10.1042/NS20170027