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Conventional protein kinase C in the brain: 40 years later

Protein kinase C (PKC) is a family of enzymes whose members transduce a large variety of cellular signals instigated by the receptor-mediated hydrolysis of membrane phospholipids. While PKC has been widely implicated in the pathology of diseases affecting all areas of physiology including cancer, di...

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Detalles Bibliográficos
Autores principales: Callender, Julia A., Newton, Alexandra C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7373245/
https://www.ncbi.nlm.nih.gov/pubmed/32714576
http://dx.doi.org/10.1042/NS20160005
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author Callender, Julia A.
Newton, Alexandra C.
author_facet Callender, Julia A.
Newton, Alexandra C.
author_sort Callender, Julia A.
collection PubMed
description Protein kinase C (PKC) is a family of enzymes whose members transduce a large variety of cellular signals instigated by the receptor-mediated hydrolysis of membrane phospholipids. While PKC has been widely implicated in the pathology of diseases affecting all areas of physiology including cancer, diabetes, and heart disease—it was discovered, and initially characterized, in the brain. PKC plays a key role in controlling the balance between cell survival and cell death. Its loss of function is generally associated with cancer, whereas its enhanced activity is associated with neurodegeneration. This review presents an overview of signaling by diacylglycerol (DG)-dependent PKC isozymes in the brain, and focuses on the role of the Ca(2+)-sensitive conventional PKC isozymes in neurodegeneration.
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spelling pubmed-73732452020-07-23 Conventional protein kinase C in the brain: 40 years later Callender, Julia A. Newton, Alexandra C. Neuronal Signal Review Articles Protein kinase C (PKC) is a family of enzymes whose members transduce a large variety of cellular signals instigated by the receptor-mediated hydrolysis of membrane phospholipids. While PKC has been widely implicated in the pathology of diseases affecting all areas of physiology including cancer, diabetes, and heart disease—it was discovered, and initially characterized, in the brain. PKC plays a key role in controlling the balance between cell survival and cell death. Its loss of function is generally associated with cancer, whereas its enhanced activity is associated with neurodegeneration. This review presents an overview of signaling by diacylglycerol (DG)-dependent PKC isozymes in the brain, and focuses on the role of the Ca(2+)-sensitive conventional PKC isozymes in neurodegeneration. Portland Press Ltd. 2017-04-10 /pmc/articles/PMC7373245/ /pubmed/32714576 http://dx.doi.org/10.1042/NS20160005 Text en © 2017 The Author(s). https://creativecommons.org/licenses/by/4.0/ This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY).
spellingShingle Review Articles
Callender, Julia A.
Newton, Alexandra C.
Conventional protein kinase C in the brain: 40 years later
title Conventional protein kinase C in the brain: 40 years later
title_full Conventional protein kinase C in the brain: 40 years later
title_fullStr Conventional protein kinase C in the brain: 40 years later
title_full_unstemmed Conventional protein kinase C in the brain: 40 years later
title_short Conventional protein kinase C in the brain: 40 years later
title_sort conventional protein kinase c in the brain: 40 years later
topic Review Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7373245/
https://www.ncbi.nlm.nih.gov/pubmed/32714576
http://dx.doi.org/10.1042/NS20160005
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