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High serum OX40 ligand correlates with severity and mortality in patients with massive cerebral infarction
OX40 ligand (OX40L) is a member of tumor necrosis factors (TNF)/TNFR superfamily and is mainly expressed in activated T cells and participates in various inflammatory reactions. However, it remains unclear about the role of serum OX40L as a biomarker of cerebral infarction (CI). This study aimed to...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer Health
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7373542/ https://www.ncbi.nlm.nih.gov/pubmed/32702829 http://dx.doi.org/10.1097/MD.0000000000020883 |
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author | Mao, Lun-Lin Chen, Wen-Ya Ma, Ai-Jin Ji, Li-Li Huang, Ting-Ting |
author_facet | Mao, Lun-Lin Chen, Wen-Ya Ma, Ai-Jin Ji, Li-Li Huang, Ting-Ting |
author_sort | Mao, Lun-Lin |
collection | PubMed |
description | OX40 ligand (OX40L) is a member of tumor necrosis factors (TNF)/TNFR superfamily and is mainly expressed in activated T cells and participates in various inflammatory reactions. However, it remains unclear about the role of serum OX40L as a biomarker of cerebral infarction (CI). This study aimed to explore the possibility of serum OX40L as a meaningful predictor in mortality of CI. Severe CI patients were included to collect clinicopathological and laboratory data and measure serum OX40L level. Patients were followed up after discharge and 60-day survival rate was used as the study endpoint. The results showed that of all 294 patients, 123 (41.8%) died within 60 days after admission. Serum OX40L levels were significantly higher in patients with severe CI compared to healthy controls, and were significantly higher in nonsurvivors compared to survivors (P < .05). The levels of OX40L were correlated with Glasgow Coma Scale score, serum creatinine and high-sensitive C-reactive protein. Multivariate logistic regression analysis showed that serum OX40L level was an independent prognostic factor for 60-day mortality, after control of pulmonary infection, glasgow coma scale score and high-sensitive C-reactive protein (odds ratio = 1.089; 95% confidence interval = 1.053–1.126; P < .001). The receiver operating characteristic (ROC) curve was used to predict the best cut-off of serum OX40L for 60-day survival as 35.5 ng/mL. Patients with high serum OX40L levels (>35.5 ng/mL) had a significantly higher mortality within 60 days (hazard ratio = 2.885; 95% confidence interval = 1.901–4.378). In conclusion, OX40L is a serum biomarker of patients with CI and associated with severity and mortality of this disease. |
format | Online Article Text |
id | pubmed-7373542 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Wolters Kluwer Health |
record_format | MEDLINE/PubMed |
spelling | pubmed-73735422020-08-05 High serum OX40 ligand correlates with severity and mortality in patients with massive cerebral infarction Mao, Lun-Lin Chen, Wen-Ya Ma, Ai-Jin Ji, Li-Li Huang, Ting-Ting Medicine (Baltimore) 5300 OX40 ligand (OX40L) is a member of tumor necrosis factors (TNF)/TNFR superfamily and is mainly expressed in activated T cells and participates in various inflammatory reactions. However, it remains unclear about the role of serum OX40L as a biomarker of cerebral infarction (CI). This study aimed to explore the possibility of serum OX40L as a meaningful predictor in mortality of CI. Severe CI patients were included to collect clinicopathological and laboratory data and measure serum OX40L level. Patients were followed up after discharge and 60-day survival rate was used as the study endpoint. The results showed that of all 294 patients, 123 (41.8%) died within 60 days after admission. Serum OX40L levels were significantly higher in patients with severe CI compared to healthy controls, and were significantly higher in nonsurvivors compared to survivors (P < .05). The levels of OX40L were correlated with Glasgow Coma Scale score, serum creatinine and high-sensitive C-reactive protein. Multivariate logistic regression analysis showed that serum OX40L level was an independent prognostic factor for 60-day mortality, after control of pulmonary infection, glasgow coma scale score and high-sensitive C-reactive protein (odds ratio = 1.089; 95% confidence interval = 1.053–1.126; P < .001). The receiver operating characteristic (ROC) curve was used to predict the best cut-off of serum OX40L for 60-day survival as 35.5 ng/mL. Patients with high serum OX40L levels (>35.5 ng/mL) had a significantly higher mortality within 60 days (hazard ratio = 2.885; 95% confidence interval = 1.901–4.378). In conclusion, OX40L is a serum biomarker of patients with CI and associated with severity and mortality of this disease. Wolters Kluwer Health 2020-07-17 /pmc/articles/PMC7373542/ /pubmed/32702829 http://dx.doi.org/10.1097/MD.0000000000020883 Text en Copyright © 2020 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by-nc/4.0 This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC), where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc/4.0 |
spellingShingle | 5300 Mao, Lun-Lin Chen, Wen-Ya Ma, Ai-Jin Ji, Li-Li Huang, Ting-Ting High serum OX40 ligand correlates with severity and mortality in patients with massive cerebral infarction |
title | High serum OX40 ligand correlates with severity and mortality in patients with massive cerebral infarction |
title_full | High serum OX40 ligand correlates with severity and mortality in patients with massive cerebral infarction |
title_fullStr | High serum OX40 ligand correlates with severity and mortality in patients with massive cerebral infarction |
title_full_unstemmed | High serum OX40 ligand correlates with severity and mortality in patients with massive cerebral infarction |
title_short | High serum OX40 ligand correlates with severity and mortality in patients with massive cerebral infarction |
title_sort | high serum ox40 ligand correlates with severity and mortality in patients with massive cerebral infarction |
topic | 5300 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7373542/ https://www.ncbi.nlm.nih.gov/pubmed/32702829 http://dx.doi.org/10.1097/MD.0000000000020883 |
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