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Optimising the dose of clonidine to achieve sedation in intensive care unit patients with population pharmacokinetics

AIMS: The aim of this study was to investigate the population pharmacokinetics (PK) of clonidine in intensive care unit (ICU) patients in order to develop a dosing regimen for sedation. METHODS: We included 24 adult mechanically ventilated, sedated patients from a mixed medical and surgical ICU. Int...

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Detalles Bibliográficos
Autores principales:	Cloesmeijer, Michael E., van den Oever, Huub L.A., Mathôt, Ron A.A., Zeeman, Marieke, Kruisdijk‐Gerritsen, Arriette, Bles, Carmen M.A., Nassikovker, Polina, de Meijer, Arthur R., van Steveninck, Fred L., Arbouw, Maurits E.L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2020
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7373711/ https://www.ncbi.nlm.nih.gov/pubmed/32150285 http://dx.doi.org/10.1111/bcp.14273

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