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Clinical Analysis of Preoperative Anti-thyroglobulin Antibody in Papillary Thyroid Cancer Between 2011 and 2015 in Beijing, China: A Retrospective Study
The anti-thyroglobulin antibody (TgAb) has been suggested to be more common in patients with papillary thyroid cancer (PTC). Here, we performed a retrospective study investigated the correlation between TgAb level and PTC in Chinese patients between 2011 and 2015. Patients with goiter who underwent...
Autores principales: | , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7373730/ https://www.ncbi.nlm.nih.gov/pubmed/32760349 http://dx.doi.org/10.3389/fendo.2020.00452 |
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author | Jia, Xiaomeng Pang, Ping Wang, Lin Zhao, Ling Jiang, Lina Song, Yeqiong Fan, Xiaojing Wang, Yajing Zhao, Sitong Ba, Jianming Yang, Guoqing Wang, Xianling Gu, Weijun Zang, Li Pei, Yu Du, Jin Mu, Yiming Lyu, Zhaohui |
author_facet | Jia, Xiaomeng Pang, Ping Wang, Lin Zhao, Ling Jiang, Lina Song, Yeqiong Fan, Xiaojing Wang, Yajing Zhao, Sitong Ba, Jianming Yang, Guoqing Wang, Xianling Gu, Weijun Zang, Li Pei, Yu Du, Jin Mu, Yiming Lyu, Zhaohui |
author_sort | Jia, Xiaomeng |
collection | PubMed |
description | The anti-thyroglobulin antibody (TgAb) has been suggested to be more common in patients with papillary thyroid cancer (PTC). Here, we performed a retrospective study investigated the correlation between TgAb level and PTC in Chinese patients between 2011 and 2015. Patients with goiter who underwent thyroidectomy and received a confirmed pathological diagnosis were enrolled into the study. Clinical characteristics and preoperative thyroglobulin antibody (TgAb) level data were collected from all enrolled patients. Based on the preoperative TgAb test results, patients were divided into a TgAb negative (TgAb–) group (<60 IU/mL) and a TgAb positive (TgAb+) group (≧60 IU/mL). Of the 4,046 patients, 671 patients were TgAb+ while 3,375 patients were TgAb–. There were 535 (79.7%) patients with PTC in the TgAb+ group, and 2,154 (63.8%) patients with PTC in the TgAb– group. The prevalance of PTC was significantly higher in TgAb+ patients than in TgAb– patients. TgAb+ patients were stratified into four groups based on the TgAb titer. The prevalence of PTC did not increase with TgAb titer. No significant difference in TgAb level was noted in patients with different clinicopathologies, including TNM stage, lymph node metastasis, and multifocal carcinoma. Regression analysis suggested a higher risk of PTC malignancy among TgAb+ patients. Preoperative TgAb level ≥60 IU/mL might be associated with a higher risk of PTC. However, there was no titer-dependent association between elevated TgAb titer and PTC malignancy. |
format | Online Article Text |
id | pubmed-7373730 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-73737302020-08-04 Clinical Analysis of Preoperative Anti-thyroglobulin Antibody in Papillary Thyroid Cancer Between 2011 and 2015 in Beijing, China: A Retrospective Study Jia, Xiaomeng Pang, Ping Wang, Lin Zhao, Ling Jiang, Lina Song, Yeqiong Fan, Xiaojing Wang, Yajing Zhao, Sitong Ba, Jianming Yang, Guoqing Wang, Xianling Gu, Weijun Zang, Li Pei, Yu Du, Jin Mu, Yiming Lyu, Zhaohui Front Endocrinol (Lausanne) Endocrinology The anti-thyroglobulin antibody (TgAb) has been suggested to be more common in patients with papillary thyroid cancer (PTC). Here, we performed a retrospective study investigated the correlation between TgAb level and PTC in Chinese patients between 2011 and 2015. Patients with goiter who underwent thyroidectomy and received a confirmed pathological diagnosis were enrolled into the study. Clinical characteristics and preoperative thyroglobulin antibody (TgAb) level data were collected from all enrolled patients. Based on the preoperative TgAb test results, patients were divided into a TgAb negative (TgAb–) group (<60 IU/mL) and a TgAb positive (TgAb+) group (≧60 IU/mL). Of the 4,046 patients, 671 patients were TgAb+ while 3,375 patients were TgAb–. There were 535 (79.7%) patients with PTC in the TgAb+ group, and 2,154 (63.8%) patients with PTC in the TgAb– group. The prevalance of PTC was significantly higher in TgAb+ patients than in TgAb– patients. TgAb+ patients were stratified into four groups based on the TgAb titer. The prevalence of PTC did not increase with TgAb titer. No significant difference in TgAb level was noted in patients with different clinicopathologies, including TNM stage, lymph node metastasis, and multifocal carcinoma. Regression analysis suggested a higher risk of PTC malignancy among TgAb+ patients. Preoperative TgAb level ≥60 IU/mL might be associated with a higher risk of PTC. However, there was no titer-dependent association between elevated TgAb titer and PTC malignancy. Frontiers Media S.A. 2020-07-15 /pmc/articles/PMC7373730/ /pubmed/32760349 http://dx.doi.org/10.3389/fendo.2020.00452 Text en Copyright © 2020 Jia, Pang, Wang, Zhao, Jiang, Song, Fan, Wang, Zhao, Ba, Yang, Wang, Gu, Zang, Pei, Du, Mu and Lyu. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Endocrinology Jia, Xiaomeng Pang, Ping Wang, Lin Zhao, Ling Jiang, Lina Song, Yeqiong Fan, Xiaojing Wang, Yajing Zhao, Sitong Ba, Jianming Yang, Guoqing Wang, Xianling Gu, Weijun Zang, Li Pei, Yu Du, Jin Mu, Yiming Lyu, Zhaohui Clinical Analysis of Preoperative Anti-thyroglobulin Antibody in Papillary Thyroid Cancer Between 2011 and 2015 in Beijing, China: A Retrospective Study |
title | Clinical Analysis of Preoperative Anti-thyroglobulin Antibody in Papillary Thyroid Cancer Between 2011 and 2015 in Beijing, China: A Retrospective Study |
title_full | Clinical Analysis of Preoperative Anti-thyroglobulin Antibody in Papillary Thyroid Cancer Between 2011 and 2015 in Beijing, China: A Retrospective Study |
title_fullStr | Clinical Analysis of Preoperative Anti-thyroglobulin Antibody in Papillary Thyroid Cancer Between 2011 and 2015 in Beijing, China: A Retrospective Study |
title_full_unstemmed | Clinical Analysis of Preoperative Anti-thyroglobulin Antibody in Papillary Thyroid Cancer Between 2011 and 2015 in Beijing, China: A Retrospective Study |
title_short | Clinical Analysis of Preoperative Anti-thyroglobulin Antibody in Papillary Thyroid Cancer Between 2011 and 2015 in Beijing, China: A Retrospective Study |
title_sort | clinical analysis of preoperative anti-thyroglobulin antibody in papillary thyroid cancer between 2011 and 2015 in beijing, china: a retrospective study |
topic | Endocrinology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7373730/ https://www.ncbi.nlm.nih.gov/pubmed/32760349 http://dx.doi.org/10.3389/fendo.2020.00452 |
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