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Schizophrenia and Sex Hormones: What Is the Link?

The involvement of gonadal hormones in the pathogenesis of schizophrenia has long been suspected because the psychosis differs in women and men and the illness first makes its appearance shortly after puberty. Changes in sex hormones have been linked with increased vulnerability to mood disorders in...

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Autores principales: Brzezinski-Sinai, Noa A., Brzezinski, Amnon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7373790/
https://www.ncbi.nlm.nih.gov/pubmed/32760302
http://dx.doi.org/10.3389/fpsyt.2020.00693
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author Brzezinski-Sinai, Noa A.
Brzezinski, Amnon
author_facet Brzezinski-Sinai, Noa A.
Brzezinski, Amnon
author_sort Brzezinski-Sinai, Noa A.
collection PubMed
description The involvement of gonadal hormones in the pathogenesis of schizophrenia has long been suspected because the psychosis differs in women and men and the illness first makes its appearance shortly after puberty. Changes in sex hormones have been linked with increased vulnerability to mood disorders in women, while testosterone have been associated with increased sexual drive and aggressiveness in men as well as women. Some studies have found abnormal levels of estrogens and testosterone in schizophrenia patients, but the results have been inconsistent and sometimes attributed to the hyperprolactinemia effect of antipsychotics, which may interfere with sex hormones production. The purpose of this review is to present the current knowledge on the link between blood levels of sex-hormones in women during the various stages of the female reproductive life (i.e. puberty, menstrual cycle, pregnancy, contraception, and menopause) and the course of schizophrenia. We also attempt to optimize the clinical approach to women with schizophrenia at these different stages.
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spelling pubmed-73737902020-08-04 Schizophrenia and Sex Hormones: What Is the Link? Brzezinski-Sinai, Noa A. Brzezinski, Amnon Front Psychiatry Psychiatry The involvement of gonadal hormones in the pathogenesis of schizophrenia has long been suspected because the psychosis differs in women and men and the illness first makes its appearance shortly after puberty. Changes in sex hormones have been linked with increased vulnerability to mood disorders in women, while testosterone have been associated with increased sexual drive and aggressiveness in men as well as women. Some studies have found abnormal levels of estrogens and testosterone in schizophrenia patients, but the results have been inconsistent and sometimes attributed to the hyperprolactinemia effect of antipsychotics, which may interfere with sex hormones production. The purpose of this review is to present the current knowledge on the link between blood levels of sex-hormones in women during the various stages of the female reproductive life (i.e. puberty, menstrual cycle, pregnancy, contraception, and menopause) and the course of schizophrenia. We also attempt to optimize the clinical approach to women with schizophrenia at these different stages. Frontiers Media S.A. 2020-07-15 /pmc/articles/PMC7373790/ /pubmed/32760302 http://dx.doi.org/10.3389/fpsyt.2020.00693 Text en Copyright © 2020 Brzezinski-Sinai and Brzezinski http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Psychiatry
Brzezinski-Sinai, Noa A.
Brzezinski, Amnon
Schizophrenia and Sex Hormones: What Is the Link?
title Schizophrenia and Sex Hormones: What Is the Link?
title_full Schizophrenia and Sex Hormones: What Is the Link?
title_fullStr Schizophrenia and Sex Hormones: What Is the Link?
title_full_unstemmed Schizophrenia and Sex Hormones: What Is the Link?
title_short Schizophrenia and Sex Hormones: What Is the Link?
title_sort schizophrenia and sex hormones: what is the link?
topic Psychiatry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7373790/
https://www.ncbi.nlm.nih.gov/pubmed/32760302
http://dx.doi.org/10.3389/fpsyt.2020.00693
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