The Cancer Dependency Map enables drug mechanism‐of‐action investigations

How do small molecules exert their effects in mammalian cells? This seemingly simple question continues to represent one of the fundamental challenges of modern translational science and as such has long been the subject of intense scientific scrutiny. In their recent study, Garnett and colleagues (...

Descripción completa

Detalles Bibliográficos
Autores principales: Vazquez, Francisca, Boehm, Jesse S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
News & Views
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7373940/
https://www.ncbi.nlm.nih.gov/pubmed/32696566
http://dx.doi.org/10.15252/msb.20209757
_version_ 1783561593716473856
author Vazquez, Francisca
Boehm, Jesse S
author_facet Vazquez, Francisca
Boehm, Jesse S
author_sort Vazquez, Francisca
collection PubMed
description How do small molecules exert their effects in mammalian cells? This seemingly simple question continues to represent one of the fundamental challenges of modern translational science and as such has long been the subject of intense scientific scrutiny. In their recent study, Garnett and colleagues (Gonçalves et al, 2020) demonstrate proof‐of‐concept for a new way to attack this problem systematically for Oncology drugs, by identifying correlated CRISPR‐ and drug‐killing profiles in the Cancer Dependency Map dataset.
format Online
Article
Text
id pubmed-7373940
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher John Wiley and Sons Inc.
record_format MEDLINE/PubMed
spelling pubmed-73739402020-07-22 The Cancer Dependency Map enables drug mechanism‐of‐action investigations Vazquez, Francisca Boehm, Jesse S Mol Syst Biol News & Views How do small molecules exert their effects in mammalian cells? This seemingly simple question continues to represent one of the fundamental challenges of modern translational science and as such has long been the subject of intense scientific scrutiny. In their recent study, Garnett and colleagues (Gonçalves et al, 2020) demonstrate proof‐of‐concept for a new way to attack this problem systematically for Oncology drugs, by identifying correlated CRISPR‐ and drug‐killing profiles in the Cancer Dependency Map dataset. John Wiley and Sons Inc. 2020-07-21 /pmc/articles/PMC7373940/ /pubmed/32696566 http://dx.doi.org/10.15252/msb.20209757 Text en © 2020 The Authors. Published under the terms of the CC BY 4.0 license This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle News & Views
Vazquez, Francisca
Boehm, Jesse S
The Cancer Dependency Map enables drug mechanism‐of‐action investigations
title The Cancer Dependency Map enables drug mechanism‐of‐action investigations
title_full The Cancer Dependency Map enables drug mechanism‐of‐action investigations
title_fullStr The Cancer Dependency Map enables drug mechanism‐of‐action investigations
title_full_unstemmed The Cancer Dependency Map enables drug mechanism‐of‐action investigations
title_short The Cancer Dependency Map enables drug mechanism‐of‐action investigations
title_sort cancer dependency map enables drug mechanism‐of‐action investigations
topic News & Views
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7373940/
https://www.ncbi.nlm.nih.gov/pubmed/32696566
http://dx.doi.org/10.15252/msb.20209757
work_keys_str_mv AT vazquezfrancisca thecancerdependencymapenablesdrugmechanismofactioninvestigations
AT boehmjesses thecancerdependencymapenablesdrugmechanismofactioninvestigations
AT vazquezfrancisca cancerdependencymapenablesdrugmechanismofactioninvestigations
AT boehmjesses cancerdependencymapenablesdrugmechanismofactioninvestigations

Ejemplares similares