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Utility of lateral flow tests in SARS-CoV-2 infection monitorization
INTRODUCTION: The diagnosis of SARS-CoV-2 infection is crucial for medical and public health reasons, to allow the best treatment of cases and the best control of the pandemic. Serology testing allows for the detection of asymptomatic infections and 19-COVID cases once the virus has been cleared. We...
Autores principales: | , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Sociedad Española de Quimioterapia
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7374028/ https://www.ncbi.nlm.nih.gov/pubmed/32492991 http://dx.doi.org/10.37201/req/052.2020 |
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author | González, Francisco Javier Candel Viñuela-Prieto, José Manuel del Castillo, Juan González García, Pablo Barreiro Saavedra, Marcos Fragiel Píriz, Alba Hernández Virumbrales, David Jiménez Lebrato, Jesús Canora de Casasola, Gonzalo García Prieto, Ruth Gil Montero, Jesús San-Román Anselmi, Justo Ortega Martín, Raquel Barba Roa, Fernando Prados Martínez, Javier Marco Gaviria, Antonio Zapatero |
author_facet | González, Francisco Javier Candel Viñuela-Prieto, José Manuel del Castillo, Juan González García, Pablo Barreiro Saavedra, Marcos Fragiel Píriz, Alba Hernández Virumbrales, David Jiménez Lebrato, Jesús Canora de Casasola, Gonzalo García Prieto, Ruth Gil Montero, Jesús San-Román Anselmi, Justo Ortega Martín, Raquel Barba Roa, Fernando Prados Martínez, Javier Marco Gaviria, Antonio Zapatero |
author_sort | González, Francisco Javier Candel |
collection | PubMed |
description | INTRODUCTION: The diagnosis of SARS-CoV-2 infection is crucial for medical and public health reasons, to allow the best treatment of cases and the best control of the pandemic. Serology testing allows for the detection of asymptomatic infections and 19-COVID cases once the virus has been cleared. We analyzed the usefulness of the SARS-CoV-2 rapid test of Autobio and tried to correlate its pattern with the severity of COVID19 infection. MATERIAL AND METHODS: We analyzed the accuracy and clinical usefulness of a point-of-care IgM and/or IgG test for SARS-CoV-2 in 35 COVID-19 patients [12 (34.3%) mild-moderate and 23 (65.7%) severe-critical] admitted to a field hospital in Madrid, as well as in 5 controls. RESULTS: The mean time from the first day of symptoms to the antibody test was 28 days (SD: 8.7), similar according to the severity of the disease. All patients with SARS-CoV-2 PCR+ showed the corresponding IgG positivity, while these results were negative in all control individuals. A total of 26 (74%) cases also presented with positive IgM, 19 (83%) were severe-critical cases and 7 (58%) were mild-moderate cases. The IgM response lasted longer in the severe critical cases (mean: 29.7 days; SD: 8.4) compared to the moderate cases (mean: 21.2 days; SD: 2.0). CONCLUSIONS: Rapid serology tests are useful for the diagnosis of patients with COVID-19 (mainly IgG detection) and may also be correlated with the severity of the infection (based on IgM detection). |
format | Online Article Text |
id | pubmed-7374028 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Sociedad Española de Quimioterapia |
record_format | MEDLINE/PubMed |
spelling | pubmed-73740282020-07-27 Utility of lateral flow tests in SARS-CoV-2 infection monitorization González, Francisco Javier Candel Viñuela-Prieto, José Manuel del Castillo, Juan González García, Pablo Barreiro Saavedra, Marcos Fragiel Píriz, Alba Hernández Virumbrales, David Jiménez Lebrato, Jesús Canora de Casasola, Gonzalo García Prieto, Ruth Gil Montero, Jesús San-Román Anselmi, Justo Ortega Martín, Raquel Barba Roa, Fernando Prados Martínez, Javier Marco Gaviria, Antonio Zapatero Rev Esp Quimioter Original INTRODUCTION: The diagnosis of SARS-CoV-2 infection is crucial for medical and public health reasons, to allow the best treatment of cases and the best control of the pandemic. Serology testing allows for the detection of asymptomatic infections and 19-COVID cases once the virus has been cleared. We analyzed the usefulness of the SARS-CoV-2 rapid test of Autobio and tried to correlate its pattern with the severity of COVID19 infection. MATERIAL AND METHODS: We analyzed the accuracy and clinical usefulness of a point-of-care IgM and/or IgG test for SARS-CoV-2 in 35 COVID-19 patients [12 (34.3%) mild-moderate and 23 (65.7%) severe-critical] admitted to a field hospital in Madrid, as well as in 5 controls. RESULTS: The mean time from the first day of symptoms to the antibody test was 28 days (SD: 8.7), similar according to the severity of the disease. All patients with SARS-CoV-2 PCR+ showed the corresponding IgG positivity, while these results were negative in all control individuals. A total of 26 (74%) cases also presented with positive IgM, 19 (83%) were severe-critical cases and 7 (58%) were mild-moderate cases. The IgM response lasted longer in the severe critical cases (mean: 29.7 days; SD: 8.4) compared to the moderate cases (mean: 21.2 days; SD: 2.0). CONCLUSIONS: Rapid serology tests are useful for the diagnosis of patients with COVID-19 (mainly IgG detection) and may also be correlated with the severity of the infection (based on IgM detection). Sociedad Española de Quimioterapia 2020-06-04 2020 /pmc/articles/PMC7374028/ /pubmed/32492991 http://dx.doi.org/10.37201/req/052.2020 Text en © The Author 2020 https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)(https://creativecommons.org/licenses/by-nc/4.0/). |
spellingShingle | Original González, Francisco Javier Candel Viñuela-Prieto, José Manuel del Castillo, Juan González García, Pablo Barreiro Saavedra, Marcos Fragiel Píriz, Alba Hernández Virumbrales, David Jiménez Lebrato, Jesús Canora de Casasola, Gonzalo García Prieto, Ruth Gil Montero, Jesús San-Román Anselmi, Justo Ortega Martín, Raquel Barba Roa, Fernando Prados Martínez, Javier Marco Gaviria, Antonio Zapatero Utility of lateral flow tests in SARS-CoV-2 infection monitorization |
title | Utility of lateral flow tests in SARS-CoV-2 infection monitorization |
title_full | Utility of lateral flow tests in SARS-CoV-2 infection monitorization |
title_fullStr | Utility of lateral flow tests in SARS-CoV-2 infection monitorization |
title_full_unstemmed | Utility of lateral flow tests in SARS-CoV-2 infection monitorization |
title_short | Utility of lateral flow tests in SARS-CoV-2 infection monitorization |
title_sort | utility of lateral flow tests in sars-cov-2 infection monitorization |
topic | Original |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7374028/ https://www.ncbi.nlm.nih.gov/pubmed/32492991 http://dx.doi.org/10.37201/req/052.2020 |
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