An Antivirulence Approach for Preventing Cryptococcus neoformans from Crossing the Blood-Brain Barrier via Novel Natural Product Inhibitors of a Fungal Metalloprotease

Cryptococcus neoformans (Cn) is the leading cause of fungal meningitis, a deadly disease with limited therapeutic options. Dissemination to the central nervous system hinges on the ability of Cn to breach the blood-brain barrier (BBB) and is considered an attribute of Cn virulence. Targeting virulen...

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Detalles Bibliográficos
Autores principales: Aaron, Phylicia A., Vu, Kiem, Gelli, Angie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7374060/
https://www.ncbi.nlm.nih.gov/pubmed/32694141
http://dx.doi.org/10.1128/mBio.01249-20

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7374060/
https://www.ncbi.nlm.nih.gov/pubmed/32694141
http://dx.doi.org/10.1128/mBio.01249-20

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