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The HERC1 ubiquitin ligase regulates presynaptic membrane dynamics of central synapses

HERC1 is a ubiquitin ligase protein, which, when mutated, induces several malformations and intellectual disability in humans. The animal model of HERC1 mutation is the mouse tambaleante characterized by: (1) overproduction of the protein; (2) cerebellar Purkinje cells death by autophagy; (3) dysreg...

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Detalles Bibliográficos
Autores principales:	Montes-Fernández, Mª Angeles, Pérez-Villegas, Eva Mª, Garcia-Gonzalo, Francesc R., Pedrazza, Leonardo, Rosa, Jose Luis, de Toledo, Guillermo Alvarez, Armengol, José A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7374096/ https://www.ncbi.nlm.nih.gov/pubmed/32694577 http://dx.doi.org/10.1038/s41598-020-68970-8

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