Cargando…

UGT2B17 modifies drug response in chronic lymphocytic leukaemia

BACKGROUND: High UGT2B17 is associated with poor prognosis in untreated chronic lymphocytic leukaemia (CLL) patients and its expression is induced in non-responders to fludarabine-containing regimens. We examined whether UGT2B17, the predominant lymphoid glucuronosyltransferase, affects leukaemic dr...

Descripción completa

Detalles Bibliográficos
Autores principales:	Allain, Eric P., Rouleau, Michèle, Vanura, Katrina, Tremblay, Sophie, Vaillancourt, Joanie, Bat, Vincent, Caron, Patrick, Villeneuve, Lyne, Labriet, Adrien, Turcotte, Véronique, Le, Trang, Shehata, Medhat, Schnabl, Susanne, Demirtas, Dita, Hubmann, Rainer, Joly-Beauparlant, Charles, Droit, Arnaud, Jäger, Ulrich, Staber, Philipp B., Lévesque, Eric, Guillemette, Chantal
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7374097/ https://www.ncbi.nlm.nih.gov/pubmed/32418995 http://dx.doi.org/10.1038/s41416-020-0887-6

Ejemplares similares

Inactivation of Prostaglandin E(2) as a Mechanism for UGT2B17-Mediated Adverse Effects in Chronic Lymphocytic Leukemia
por: Allain, Eric P., et al.
Publicado: (2019)

Alternative promoters control UGT2B17-dependent androgen catabolism in prostate cancer and its influence on progression
por: Lévesque, Eric, et al.
Publicado: (2020)

Reply to Comment on “UGT2B17 modifies drug response in chronic lymphocytic leukaemia”
por: Guillemette, Chantal, et al.
Publicado: (2020)

A Non-Canonical Role for the Glycosyltransferase Enzyme UGT2B17 as a Novel Constituent of the B Cell Receptor Signalosome
por: Wagner, Antoine, et al.
Publicado: (2023)

Germline variability and tumor expression level of ribosomal protein gene RPL28 are associated with survival of metastatic colorectal cancer patients
por: Labriet, Adrien, et al.
Publicado: (2019)

Targeting Nuclear NOTCH2 by Gliotoxin Recovers a Tumor-Suppressor NOTCH3 Activity in CLL
por: Hubmann, Rainer, et al.
Publicado: (2020)

Sex-dependent association of circulating sex steroids and pituitary hormones with treatment-free survival in chronic lymphocytic leukemia patients
por: Allain, Eric P., et al.
Publicado: (2018)

Gliotoxin Targets Nuclear NOTCH2 in Human Solid Tumor Derived Cell Lines In Vitro and Inhibits Melanoma Growth in Xenograft Mouse Model
por: Hubmann, Rainer, et al.
Publicado: (2017)

Emerging roles for UDP-glucuronosyltransferases in drug resistance and cancer progression
por: Allain, Eric P., et al.
Publicado: (2020)

Improved Progression-Free Survival in Irinotecan-Treated Metastatic Colorectal Cancer Patients Carrying the HNF1A Coding Variant p.I27L
por: Labriet, Adrien, et al.
Publicado: (2017)

The Glycosyltransferase Pathway: An Integrated Analysis of the Cell Metabolome
por: Audet-Delage, Yannick, et al.
Publicado: (2022)

Untargeted metabolomics identifies metabolic dysregulation of sphingolipids associated with aggressive chronic lymphocytic leukaemia and poor survival
por: Nguyen Van Long, Flora, et al.
Publicado: (2023)

Cis-regulatory hubs: a new 3D model of complex disease genetics with an application to schizophrenia
por: Mangnier, Loïc, et al.
Publicado: (2022)

RNA sequencing data of human prostate cancer cells treated with androgens
por: Poluri, Raghavendra Tejo Karthik, et al.
Publicado: (2019)

DIA proteomics data from a UPS1-spiked E.coli protein mixture processed with six software tools
por: Gotti, Clarisse, et al.
Publicado: (2022)

Extensive metabolic consequences of human glycosyltransferase gene knockouts in prostate cancer
por: Rouleau, Michèle, et al.
Publicado: (2022)

Identification of Metabolomic Biomarkers for Endometrial Cancer and Its Recurrence after Surgery in Postmenopausal Women
por: Audet-Delage, Yannick, et al.
Publicado: (2018)

HCK and ABAA: A Newly Designed Pipeline to Improve Fungi Metabarcoding Analysis
por: Mlaga, Kodjovi D., et al.
Publicado: (2021)

FOXA and master transcription factors recruit Mediator and Cohesin to the core transcriptional regulatory circuitry of cancer cells
por: Fournier, Michèle, et al.
Publicado: (2016)

metagene Profiles Analyses Reveal Regulatory Element’s Factor-Specific Recruitment Patterns
por: Joly Beauparlant, Charles, et al.
Publicado: (2016)

Transcriptional signature of lymphoblastoid cell lines of BRCA1, BRCA2 and non-BRCA1/2 high risk breast cancer families
por: Pouliot, Marie-Christine, et al.
Publicado: (2017)

Regulation of UGT1A1 and HNF1 transcription factor gene expression by DNA methylation in colon cancer cells
por: Bélanger, Anne-Sophie, et al.
Publicado: (2010)

IL15RA and SMAD3 Genetic Variants Predict Overall Survival in Metastatic Colorectal Cancer Patients Treated with FOLFIRI Therapy: A New Paradigm
por: De Mattia, Elena, et al.
Publicado: (2021)

Impacts of the Glucuronidase Genotypes UGT1A4, UGT2B7, UGT2B15 and UGT2B17 on Tamoxifen Metabolism in Breast Cancer Patients
por: Romero-Lorca, Alicia, et al.
Publicado: (2015)

Correction: Impacts of the Glucuronidase Genotypes UGT1A4, UGT2B7, UGT2B15 and UGT2B17 on Tamoxifen Metabolism in Breast Cancer Patients
Publicado: (2015)

Differences in UGT1A1, UGT1A7, and UGT1A9 Polymorphisms between Uzbek and Japanese Populations
por: Maeda, Hiromichi, et al.
Publicado: (2014)

Cannabinoid Receptors Are Overexpressed in CLL but of Limited Potential for Therapeutic Exploitation
por: Freund, Patricia, et al.
Publicado: (2016)

Multi-Omics Data Integration Reveals Key Variables Contributing to Subgingival Microbiome Dysbiosis-Induced Inflammatory Response in a Hyperglycemic Microenvironment
por: Lafleur, Sarah, et al.
Publicado: (2023)

Historia de la UGT.
Publicado: (2008)

Predicting Flavonoid UGT Regioselectivity
por: Jackson, Rhydon, et al.
Publicado: (2011)

Association of STAT-3 rs1053004 and VDR rs11574077 With FOLFIRI-Related Gastrointestinal Toxicity in Metastatic Colorectal Cancer Patients
por: De Mattia, Elena, et al.
Publicado: (2018)

Germline Polymorphisms in the Nuclear Receptors PXR and VDR as Novel Prognostic Markers in Metastatic Colorectal Cancer Patients Treated With FOLFIRI
por: De Mattia, Elena, et al.
Publicado: (2019)

Profiling of UGT1A1(*)6, UGT1A1(*)60, UGT1A1(*)93, and UGT1A1(*)28 Polymorphisms in Indonesian Neonates With Hyperbilirubinemia Using Multiplex PCR Sequencing
por: Amandito, Radhian, et al.
Publicado: (2019)

Uridine Diphosphate Glucuronosyl Transferase 2B28 (UGT2B28) Promotes Tumor Progression and Is Elevated in African American Prostate Cancer Patients
por: Ravindran, Anindita, et al.
Publicado: (2022)

Commentary: Profiling of UGT1A1(*)6, UGT1A1(*)60, UGT1A1(*)93, and UGT1A1(*)28 Polymorphisms in Indonesian Neonates With Hyperbilirubinemia Using Multiplex PCR Sequencing
por: Heydari, Mohammad Reza, et al.
Publicado: (2020)

Polymorphisms of UGT1A1(*)6, UGT1A1(*)27 & UGT1A1(*)28 in three major ethnic groups from Malaysia
por: Teh, L. K., et al.
Publicado: (2012)

Epigenetics and microRNAs in UGT1As
por: Meng, Cui-Lan, et al.
Publicado: (2021)

Complete Reaction Phenotyping of Propranolol and 4-Hydroxypropranolol with the 19 Enzymes of the Human UGT1 and UGT2 Families
por: Yang, Fan, et al.
Publicado: (2022)

Genome-Wide Analysis of UGT Genes in Petunia and Identification of PhUGT51 Involved in the Regulation of Salt Resistance
por: Dong, Lili, et al.
Publicado: (2022)

Genotyping of UGT1A1*80 as an Alternative to UGT1A1*28 Genotyping in Spain
por: Bravo-Gómez, Adrián, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_j391rfkeubkkoftn325lke4n90