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Effects of add-on transcranial direct current stimulation on pain in Korean patients with fibromyalgia
Despite promising preliminary results of transcranial direct current stimulation (tDCS) treatment in patients with fibromyalgia (FM), several issues need to be addressed, including its limited efficacy, low response rate, and poor tolerability. We investigated the efficacy and safety of tDCS as an a...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7374102/ https://www.ncbi.nlm.nih.gov/pubmed/32694653 http://dx.doi.org/10.1038/s41598-020-69131-7 |
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author | Kang, Ji-Hyoun Choi, Sung-Eun Park, Dong-Jin Xu, Haimuzi Lee, Jung-Kil Lee, Shin-Seok |
author_facet | Kang, Ji-Hyoun Choi, Sung-Eun Park, Dong-Jin Xu, Haimuzi Lee, Jung-Kil Lee, Shin-Seok |
author_sort | Kang, Ji-Hyoun |
collection | PubMed |
description | Despite promising preliminary results of transcranial direct current stimulation (tDCS) treatment in patients with fibromyalgia (FM), several issues need to be addressed, including its limited efficacy, low response rate, and poor tolerability. We investigated the efficacy and safety of tDCS as an add-on treatment for chronic pain in Korean patients with FM. This study enrolled 46 patients who were refractory to pain medications from May 2016 to February 2017. A conventional tDCS device was used to supply 2 mA of current for 20 min on five consecutive days. The primary end-point was a change in visual analogue scale (VAS) pain score at the end of treatment; secondary end-points included changes in Fibromyalgia Impact Questionnaire (FIQ), Brief Pain Inventory (BPI), Brief Fatigue Inventory (BFI), Beck Depression Inventory (BDI), State-Trait Anxiety Inventory (STAI), and Medical Outcomes Study Sleep Scale (MOS-SS) scores. After tDCS, 46 patients showed clinical improvements in VAS pain scores on days 6, 13, and 36 compared with day 0 (p < 0.001). Improvement in FIQ was seen on day 13. The BDI decreased significantly on days 6 and 36, and BFI improved significantly on days 6 and 13. There were no significant improvements in STAI-I, STAI-II, and MOS-SS scores after tDCS. No serious adverse events were observed. Our results suggest that tDCS can result in significant pain relief in FM patients and may be an effective add-on treatment. |
format | Online Article Text |
id | pubmed-7374102 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-73741022020-07-22 Effects of add-on transcranial direct current stimulation on pain in Korean patients with fibromyalgia Kang, Ji-Hyoun Choi, Sung-Eun Park, Dong-Jin Xu, Haimuzi Lee, Jung-Kil Lee, Shin-Seok Sci Rep Article Despite promising preliminary results of transcranial direct current stimulation (tDCS) treatment in patients with fibromyalgia (FM), several issues need to be addressed, including its limited efficacy, low response rate, and poor tolerability. We investigated the efficacy and safety of tDCS as an add-on treatment for chronic pain in Korean patients with FM. This study enrolled 46 patients who were refractory to pain medications from May 2016 to February 2017. A conventional tDCS device was used to supply 2 mA of current for 20 min on five consecutive days. The primary end-point was a change in visual analogue scale (VAS) pain score at the end of treatment; secondary end-points included changes in Fibromyalgia Impact Questionnaire (FIQ), Brief Pain Inventory (BPI), Brief Fatigue Inventory (BFI), Beck Depression Inventory (BDI), State-Trait Anxiety Inventory (STAI), and Medical Outcomes Study Sleep Scale (MOS-SS) scores. After tDCS, 46 patients showed clinical improvements in VAS pain scores on days 6, 13, and 36 compared with day 0 (p < 0.001). Improvement in FIQ was seen on day 13. The BDI decreased significantly on days 6 and 36, and BFI improved significantly on days 6 and 13. There were no significant improvements in STAI-I, STAI-II, and MOS-SS scores after tDCS. No serious adverse events were observed. Our results suggest that tDCS can result in significant pain relief in FM patients and may be an effective add-on treatment. Nature Publishing Group UK 2020-07-21 /pmc/articles/PMC7374102/ /pubmed/32694653 http://dx.doi.org/10.1038/s41598-020-69131-7 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Kang, Ji-Hyoun Choi, Sung-Eun Park, Dong-Jin Xu, Haimuzi Lee, Jung-Kil Lee, Shin-Seok Effects of add-on transcranial direct current stimulation on pain in Korean patients with fibromyalgia |
title | Effects of add-on transcranial direct current stimulation on pain in Korean patients with fibromyalgia |
title_full | Effects of add-on transcranial direct current stimulation on pain in Korean patients with fibromyalgia |
title_fullStr | Effects of add-on transcranial direct current stimulation on pain in Korean patients with fibromyalgia |
title_full_unstemmed | Effects of add-on transcranial direct current stimulation on pain in Korean patients with fibromyalgia |
title_short | Effects of add-on transcranial direct current stimulation on pain in Korean patients with fibromyalgia |
title_sort | effects of add-on transcranial direct current stimulation on pain in korean patients with fibromyalgia |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7374102/ https://www.ncbi.nlm.nih.gov/pubmed/32694653 http://dx.doi.org/10.1038/s41598-020-69131-7 |
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