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Effects of thyroid dysfunction on hematological parameters: Case controlled study
INTRODUCTION: The thyroid gland has a very important role in hematopoiesis, blood disorders are frequently seen in patients with thyroid disorders. Thyroid hormones have direct effect on blood parameters by stimulating erythrocytes precursors and indirectly by enhancing erythropoietin production. PA...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7374177/ https://www.ncbi.nlm.nih.gov/pubmed/32714526 http://dx.doi.org/10.1016/j.amsu.2020.07.008 |
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author | Ahmed, Sawer Sabri Mohammed, Ayad Ahmad |
author_facet | Ahmed, Sawer Sabri Mohammed, Ayad Ahmad |
author_sort | Ahmed, Sawer Sabri |
collection | PubMed |
description | INTRODUCTION: The thyroid gland has a very important role in hematopoiesis, blood disorders are frequently seen in patients with thyroid disorders. Thyroid hormones have direct effect on blood parameters by stimulating erythrocytes precursors and indirectly by enhancing erythropoietin production. PATIENTS AND METHODS: This is a case-control study which included 300 subjects who were grouped to 3 equal groups as a control, hypothyroidism, and hyperthyroidism groups. Patients with inherited or acquired red cell abnormalities, those receiving treatment for thyroid disorder or anemia, patient with chronic diseases, aged <12 years, pregnant ladies and patients unwilling to participate in the study were excluded. RESULTS: The mean age of patients is 40.72 years, and females constituted 60.7% of cases. The analyses showed a significant difference the RBC, HB, MCV, MCHC, RDW, and WBC (P values 0.000, 0.000, 0.001, 0.012.0.002, and 0.027) respectively, while platelets showed no significant correlation (P value 0.08). The univariate analyses showed that RBC, the HB, and the WBC were the most severely affected parameters (Sig. 0.000, 0.000, and 0.005) respectively. CONCLUSION: The study concluded that females are more affected by thyroid disorders than males and the peak age is at the forties, thyroid dysfunction affect all blood parameters except platelets.The follow up of patients with thyroid disorders should include the complete blood count and patients diagnosed with anemia should be evaluated for thyroid disorders before iron therapy. Cases of anemia that resist treatment should be investigated for the possibility of thyroid dysfunction. |
format | Online Article Text |
id | pubmed-7374177 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-73741772020-07-23 Effects of thyroid dysfunction on hematological parameters: Case controlled study Ahmed, Sawer Sabri Mohammed, Ayad Ahmad Ann Med Surg (Lond) Original Research INTRODUCTION: The thyroid gland has a very important role in hematopoiesis, blood disorders are frequently seen in patients with thyroid disorders. Thyroid hormones have direct effect on blood parameters by stimulating erythrocytes precursors and indirectly by enhancing erythropoietin production. PATIENTS AND METHODS: This is a case-control study which included 300 subjects who were grouped to 3 equal groups as a control, hypothyroidism, and hyperthyroidism groups. Patients with inherited or acquired red cell abnormalities, those receiving treatment for thyroid disorder or anemia, patient with chronic diseases, aged <12 years, pregnant ladies and patients unwilling to participate in the study were excluded. RESULTS: The mean age of patients is 40.72 years, and females constituted 60.7% of cases. The analyses showed a significant difference the RBC, HB, MCV, MCHC, RDW, and WBC (P values 0.000, 0.000, 0.001, 0.012.0.002, and 0.027) respectively, while platelets showed no significant correlation (P value 0.08). The univariate analyses showed that RBC, the HB, and the WBC were the most severely affected parameters (Sig. 0.000, 0.000, and 0.005) respectively. CONCLUSION: The study concluded that females are more affected by thyroid disorders than males and the peak age is at the forties, thyroid dysfunction affect all blood parameters except platelets.The follow up of patients with thyroid disorders should include the complete blood count and patients diagnosed with anemia should be evaluated for thyroid disorders before iron therapy. Cases of anemia that resist treatment should be investigated for the possibility of thyroid dysfunction. Elsevier 2020-07-11 /pmc/articles/PMC7374177/ /pubmed/32714526 http://dx.doi.org/10.1016/j.amsu.2020.07.008 Text en © 2020 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Original Research Ahmed, Sawer Sabri Mohammed, Ayad Ahmad Effects of thyroid dysfunction on hematological parameters: Case controlled study |
title | Effects of thyroid dysfunction on hematological parameters: Case controlled study |
title_full | Effects of thyroid dysfunction on hematological parameters: Case controlled study |
title_fullStr | Effects of thyroid dysfunction on hematological parameters: Case controlled study |
title_full_unstemmed | Effects of thyroid dysfunction on hematological parameters: Case controlled study |
title_short | Effects of thyroid dysfunction on hematological parameters: Case controlled study |
title_sort | effects of thyroid dysfunction on hematological parameters: case controlled study |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7374177/ https://www.ncbi.nlm.nih.gov/pubmed/32714526 http://dx.doi.org/10.1016/j.amsu.2020.07.008 |
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