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Effects of thyroid dysfunction on hematological parameters: Case controlled study

INTRODUCTION: The thyroid gland has a very important role in hematopoiesis, blood disorders are frequently seen in patients with thyroid disorders. Thyroid hormones have direct effect on blood parameters by stimulating erythrocytes precursors and indirectly by enhancing erythropoietin production. PA...

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Autores principales: Ahmed, Sawer Sabri, Mohammed, Ayad Ahmad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7374177/
https://www.ncbi.nlm.nih.gov/pubmed/32714526
http://dx.doi.org/10.1016/j.amsu.2020.07.008
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author Ahmed, Sawer Sabri
Mohammed, Ayad Ahmad
author_facet Ahmed, Sawer Sabri
Mohammed, Ayad Ahmad
author_sort Ahmed, Sawer Sabri
collection PubMed
description INTRODUCTION: The thyroid gland has a very important role in hematopoiesis, blood disorders are frequently seen in patients with thyroid disorders. Thyroid hormones have direct effect on blood parameters by stimulating erythrocytes precursors and indirectly by enhancing erythropoietin production. PATIENTS AND METHODS: This is a case-control study which included 300 subjects who were grouped to 3 equal groups as a control, hypothyroidism, and hyperthyroidism groups. Patients with inherited or acquired red cell abnormalities, those receiving treatment for thyroid disorder or anemia, patient with chronic diseases, aged <12 years, pregnant ladies and patients unwilling to participate in the study were excluded. RESULTS: The mean age of patients is 40.72 years, and females constituted 60.7% of cases. The analyses showed a significant difference the RBC, HB, MCV, MCHC, RDW, and WBC (P values 0.000, 0.000, 0.001, 0.012.0.002, and 0.027) respectively, while platelets showed no significant correlation (P value 0.08). The univariate analyses showed that RBC, the HB, and the WBC were the most severely affected parameters (Sig. 0.000, 0.000, and 0.005) respectively. CONCLUSION: The study concluded that females are more affected by thyroid disorders than males and the peak age is at the forties, thyroid dysfunction affect all blood parameters except platelets.The follow up of patients with thyroid disorders should include the complete blood count and patients diagnosed with anemia should be evaluated for thyroid disorders before iron therapy. Cases of anemia that resist treatment should be investigated for the possibility of thyroid dysfunction.
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spelling pubmed-73741772020-07-23 Effects of thyroid dysfunction on hematological parameters: Case controlled study Ahmed, Sawer Sabri Mohammed, Ayad Ahmad Ann Med Surg (Lond) Original Research INTRODUCTION: The thyroid gland has a very important role in hematopoiesis, blood disorders are frequently seen in patients with thyroid disorders. Thyroid hormones have direct effect on blood parameters by stimulating erythrocytes precursors and indirectly by enhancing erythropoietin production. PATIENTS AND METHODS: This is a case-control study which included 300 subjects who were grouped to 3 equal groups as a control, hypothyroidism, and hyperthyroidism groups. Patients with inherited or acquired red cell abnormalities, those receiving treatment for thyroid disorder or anemia, patient with chronic diseases, aged <12 years, pregnant ladies and patients unwilling to participate in the study were excluded. RESULTS: The mean age of patients is 40.72 years, and females constituted 60.7% of cases. The analyses showed a significant difference the RBC, HB, MCV, MCHC, RDW, and WBC (P values 0.000, 0.000, 0.001, 0.012.0.002, and 0.027) respectively, while platelets showed no significant correlation (P value 0.08). The univariate analyses showed that RBC, the HB, and the WBC were the most severely affected parameters (Sig. 0.000, 0.000, and 0.005) respectively. CONCLUSION: The study concluded that females are more affected by thyroid disorders than males and the peak age is at the forties, thyroid dysfunction affect all blood parameters except platelets.The follow up of patients with thyroid disorders should include the complete blood count and patients diagnosed with anemia should be evaluated for thyroid disorders before iron therapy. Cases of anemia that resist treatment should be investigated for the possibility of thyroid dysfunction. Elsevier 2020-07-11 /pmc/articles/PMC7374177/ /pubmed/32714526 http://dx.doi.org/10.1016/j.amsu.2020.07.008 Text en © 2020 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Original Research
Ahmed, Sawer Sabri
Mohammed, Ayad Ahmad
Effects of thyroid dysfunction on hematological parameters: Case controlled study
title Effects of thyroid dysfunction on hematological parameters: Case controlled study
title_full Effects of thyroid dysfunction on hematological parameters: Case controlled study
title_fullStr Effects of thyroid dysfunction on hematological parameters: Case controlled study
title_full_unstemmed Effects of thyroid dysfunction on hematological parameters: Case controlled study
title_short Effects of thyroid dysfunction on hematological parameters: Case controlled study
title_sort effects of thyroid dysfunction on hematological parameters: case controlled study
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7374177/
https://www.ncbi.nlm.nih.gov/pubmed/32714526
http://dx.doi.org/10.1016/j.amsu.2020.07.008
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