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Experimental determination of indoor air concentration of 5-chloro-2-methylisothiazol-3(2H)-one/ 2-methylisothiazol-3(2H)-one (CMIT/MIT) emitted by the use of humidifier disinfectant

A mixture of 5-chloro-2-methylisothiazol-3(2H)-one/2-methylisothiazol-3(2H)-one (CMIT/MIT) had been used as an active ingredient in humidifier disinfectants (HDs). Owing to its high reactivity, the atmospheric concentration of CMIT/MIT, following its use in HD, would be lower than expected assuming...

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Autores principales: Park, Seon-Kyung, Seol, Hwi-Soo, Park, Hee-Jin, Kim, Yoon-Seob, Ryu, Seung-Hun, Kim, Jaehoon, Kim, Suejin, Lee, Jong-Hyeon, Kwon, Jung-Hwan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Society of Environmental Health and Toxicology/Korea Society for Environmental Analysis 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7374189/
https://www.ncbi.nlm.nih.gov/pubmed/32600006
http://dx.doi.org/10.5620/eaht.e2020008
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author Park, Seon-Kyung
Seol, Hwi-Soo
Park, Hee-Jin
Kim, Yoon-Seob
Ryu, Seung-Hun
Kim, Jaehoon
Kim, Suejin
Lee, Jong-Hyeon
Kwon, Jung-Hwan
author_facet Park, Seon-Kyung
Seol, Hwi-Soo
Park, Hee-Jin
Kim, Yoon-Seob
Ryu, Seung-Hun
Kim, Jaehoon
Kim, Suejin
Lee, Jong-Hyeon
Kwon, Jung-Hwan
author_sort Park, Seon-Kyung
collection PubMed
description A mixture of 5-chloro-2-methylisothiazol-3(2H)-one/2-methylisothiazol-3(2H)-one (CMIT/MIT) had been used as an active ingredient in humidifier disinfectants (HDs). Owing to its high reactivity, the atmospheric concentration of CMIT/MIT, following its use in HD, would be lower than expected assuming that it is removed by ventilation only. In order to evaluate the exposure concentration of CMIT/MIT used as an HD, room-scale chamber studies were conducted under plausible use of three different HD doses at air change rates (ACR) of 0.3, 0.5, and 1.0 h(−1). Atmospheric CMIT/MIT was sampled using two serial impingers containing deionized water after the attainment of steady state. Water samples in which CMIT/MIT was dissolved were concentrated using a cosolvent evaporation method with efficiencies of 35.5 and 77.9% for CMIT and MIT, respectively. The estimated air concentration, assuming that all the CMIT/MIT is absorbed in deionized water, increased linearly with increasing emission rate, but was independent of the ACR. This indicates that the removal rate of CMIT/MIT via chemical reactions is more than the removal rate by ventilation. Further investigations on homogeneous and heterogeneous chemical reactions of CMIT/MIT under ambient conditions are necessary to understand the actual exposure concentration of the mixture in HD.
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spelling pubmed-73741892020-07-29 Experimental determination of indoor air concentration of 5-chloro-2-methylisothiazol-3(2H)-one/ 2-methylisothiazol-3(2H)-one (CMIT/MIT) emitted by the use of humidifier disinfectant Park, Seon-Kyung Seol, Hwi-Soo Park, Hee-Jin Kim, Yoon-Seob Ryu, Seung-Hun Kim, Jaehoon Kim, Suejin Lee, Jong-Hyeon Kwon, Jung-Hwan Environ Anal Health Toxicol Original Article A mixture of 5-chloro-2-methylisothiazol-3(2H)-one/2-methylisothiazol-3(2H)-one (CMIT/MIT) had been used as an active ingredient in humidifier disinfectants (HDs). Owing to its high reactivity, the atmospheric concentration of CMIT/MIT, following its use in HD, would be lower than expected assuming that it is removed by ventilation only. In order to evaluate the exposure concentration of CMIT/MIT used as an HD, room-scale chamber studies were conducted under plausible use of three different HD doses at air change rates (ACR) of 0.3, 0.5, and 1.0 h(−1). Atmospheric CMIT/MIT was sampled using two serial impingers containing deionized water after the attainment of steady state. Water samples in which CMIT/MIT was dissolved were concentrated using a cosolvent evaporation method with efficiencies of 35.5 and 77.9% for CMIT and MIT, respectively. The estimated air concentration, assuming that all the CMIT/MIT is absorbed in deionized water, increased linearly with increasing emission rate, but was independent of the ACR. This indicates that the removal rate of CMIT/MIT via chemical reactions is more than the removal rate by ventilation. Further investigations on homogeneous and heterogeneous chemical reactions of CMIT/MIT under ambient conditions are necessary to understand the actual exposure concentration of the mixture in HD. Korean Society of Environmental Health and Toxicology/Korea Society for Environmental Analysis 2020-06-30 /pmc/articles/PMC7374189/ /pubmed/32600006 http://dx.doi.org/10.5620/eaht.e2020008 Text en Copyright © 2020 The Korean Society of Environmental Health and Toxicology/Korea Society for Environmental Analysis This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Park, Seon-Kyung
Seol, Hwi-Soo
Park, Hee-Jin
Kim, Yoon-Seob
Ryu, Seung-Hun
Kim, Jaehoon
Kim, Suejin
Lee, Jong-Hyeon
Kwon, Jung-Hwan
Experimental determination of indoor air concentration of 5-chloro-2-methylisothiazol-3(2H)-one/ 2-methylisothiazol-3(2H)-one (CMIT/MIT) emitted by the use of humidifier disinfectant
title Experimental determination of indoor air concentration of 5-chloro-2-methylisothiazol-3(2H)-one/ 2-methylisothiazol-3(2H)-one (CMIT/MIT) emitted by the use of humidifier disinfectant
title_full Experimental determination of indoor air concentration of 5-chloro-2-methylisothiazol-3(2H)-one/ 2-methylisothiazol-3(2H)-one (CMIT/MIT) emitted by the use of humidifier disinfectant
title_fullStr Experimental determination of indoor air concentration of 5-chloro-2-methylisothiazol-3(2H)-one/ 2-methylisothiazol-3(2H)-one (CMIT/MIT) emitted by the use of humidifier disinfectant
title_full_unstemmed Experimental determination of indoor air concentration of 5-chloro-2-methylisothiazol-3(2H)-one/ 2-methylisothiazol-3(2H)-one (CMIT/MIT) emitted by the use of humidifier disinfectant
title_short Experimental determination of indoor air concentration of 5-chloro-2-methylisothiazol-3(2H)-one/ 2-methylisothiazol-3(2H)-one (CMIT/MIT) emitted by the use of humidifier disinfectant
title_sort experimental determination of indoor air concentration of 5-chloro-2-methylisothiazol-3(2h)-one/ 2-methylisothiazol-3(2h)-one (cmit/mit) emitted by the use of humidifier disinfectant
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7374189/
https://www.ncbi.nlm.nih.gov/pubmed/32600006
http://dx.doi.org/10.5620/eaht.e2020008
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