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High Occurrence of Thrombo-Embolic Complications During Long-Term Follow-up After Pleural Infections—A Single-Center Experience with 536 Consecutive Patients Over 17 Years
PURPOSE: Pleural infections are associated with significant inflammation, long hospitalizations, frequent comorbidities, and are often treated operatively—all of which are consequential risk factors for thrombo-embolic complications. However, their occurrence following the treatment of pleural infec...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer US
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7374478/ https://www.ncbi.nlm.nih.gov/pubmed/32607673 http://dx.doi.org/10.1007/s00408-020-00374-x |
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author | Ala-Seppälä, Henna Maria Ukkonen, Mika Tapani Lehtomäki, Antti Ilmari Pohja, Emilia Susanna Nieminen, Jaakko Juhani Laurikka, Jari Olavi Khan, Jahangir Ari |
author_facet | Ala-Seppälä, Henna Maria Ukkonen, Mika Tapani Lehtomäki, Antti Ilmari Pohja, Emilia Susanna Nieminen, Jaakko Juhani Laurikka, Jari Olavi Khan, Jahangir Ari |
author_sort | Ala-Seppälä, Henna Maria |
collection | PubMed |
description | PURPOSE: Pleural infections are associated with significant inflammation, long hospitalizations, frequent comorbidities, and are often treated operatively—all of which are consequential risk factors for thrombo-embolic complications. However, their occurrence following the treatment of pleural infection is still unknown. The aim of the study was to ascertain the early and long-term occurrence of thrombo-embolic events in patients treated for pleural infections. METHODS: The study included all patients that were treated for pleural infections in Tampere University Hospital between January 2000 and December 2016. Data regarding later treatment episodes due to pulmonary embolisms and/or deep vein thromboses as well as survival data were requested from national registries. The rates were also compared to a demographically matched reference population adjusted for age, sex, and the location of residence. RESULTS: The final study population comprised 536 patients and 5318 controls (median age 60, 78% men). The most common etiology for pleural infection was pneumonia (73%) and 85% underwent surgical treatment for pleural infection. The occurrence of thrombo-embolic complications in patients and controls was 3.8% vs 0.1% at three months, 5.0% vs 0.4% at one year, 8.8% vs 1.0% at three years, and 12.4% vs 1.8% at five years, respectively, p < 0.001 each. Female sex, advanced age, chronic lung disease, immunosuppression, video-assisted surgery, and non-pneumonic etiology were associated with a higher incidence of thrombo-embolism. CONCLUSIONS: The occurrence of thrombo-embolic events—particularly pulmonary embolism but also deep vein thrombosis—was significant in patients treated for pleural infections, both initially and during long-term follow-up. |
format | Online Article Text |
id | pubmed-7374478 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Springer US |
record_format | MEDLINE/PubMed |
spelling | pubmed-73744782020-07-27 High Occurrence of Thrombo-Embolic Complications During Long-Term Follow-up After Pleural Infections—A Single-Center Experience with 536 Consecutive Patients Over 17 Years Ala-Seppälä, Henna Maria Ukkonen, Mika Tapani Lehtomäki, Antti Ilmari Pohja, Emilia Susanna Nieminen, Jaakko Juhani Laurikka, Jari Olavi Khan, Jahangir Ari Lung Pleural Infection and Thromboembolic Complications PURPOSE: Pleural infections are associated with significant inflammation, long hospitalizations, frequent comorbidities, and are often treated operatively—all of which are consequential risk factors for thrombo-embolic complications. However, their occurrence following the treatment of pleural infection is still unknown. The aim of the study was to ascertain the early and long-term occurrence of thrombo-embolic events in patients treated for pleural infections. METHODS: The study included all patients that were treated for pleural infections in Tampere University Hospital between January 2000 and December 2016. Data regarding later treatment episodes due to pulmonary embolisms and/or deep vein thromboses as well as survival data were requested from national registries. The rates were also compared to a demographically matched reference population adjusted for age, sex, and the location of residence. RESULTS: The final study population comprised 536 patients and 5318 controls (median age 60, 78% men). The most common etiology for pleural infection was pneumonia (73%) and 85% underwent surgical treatment for pleural infection. The occurrence of thrombo-embolic complications in patients and controls was 3.8% vs 0.1% at three months, 5.0% vs 0.4% at one year, 8.8% vs 1.0% at three years, and 12.4% vs 1.8% at five years, respectively, p < 0.001 each. Female sex, advanced age, chronic lung disease, immunosuppression, video-assisted surgery, and non-pneumonic etiology were associated with a higher incidence of thrombo-embolism. CONCLUSIONS: The occurrence of thrombo-embolic events—particularly pulmonary embolism but also deep vein thrombosis—was significant in patients treated for pleural infections, both initially and during long-term follow-up. Springer US 2020-06-30 2020 /pmc/articles/PMC7374478/ /pubmed/32607673 http://dx.doi.org/10.1007/s00408-020-00374-x Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Pleural Infection and Thromboembolic Complications Ala-Seppälä, Henna Maria Ukkonen, Mika Tapani Lehtomäki, Antti Ilmari Pohja, Emilia Susanna Nieminen, Jaakko Juhani Laurikka, Jari Olavi Khan, Jahangir Ari High Occurrence of Thrombo-Embolic Complications During Long-Term Follow-up After Pleural Infections—A Single-Center Experience with 536 Consecutive Patients Over 17 Years |
title | High Occurrence of Thrombo-Embolic Complications During Long-Term Follow-up After Pleural Infections—A Single-Center Experience with 536 Consecutive Patients Over 17 Years |
title_full | High Occurrence of Thrombo-Embolic Complications During Long-Term Follow-up After Pleural Infections—A Single-Center Experience with 536 Consecutive Patients Over 17 Years |
title_fullStr | High Occurrence of Thrombo-Embolic Complications During Long-Term Follow-up After Pleural Infections—A Single-Center Experience with 536 Consecutive Patients Over 17 Years |
title_full_unstemmed | High Occurrence of Thrombo-Embolic Complications During Long-Term Follow-up After Pleural Infections—A Single-Center Experience with 536 Consecutive Patients Over 17 Years |
title_short | High Occurrence of Thrombo-Embolic Complications During Long-Term Follow-up After Pleural Infections—A Single-Center Experience with 536 Consecutive Patients Over 17 Years |
title_sort | high occurrence of thrombo-embolic complications during long-term follow-up after pleural infections—a single-center experience with 536 consecutive patients over 17 years |
topic | Pleural Infection and Thromboembolic Complications |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7374478/ https://www.ncbi.nlm.nih.gov/pubmed/32607673 http://dx.doi.org/10.1007/s00408-020-00374-x |
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