Cargando…

High Occurrence of Thrombo-Embolic Complications During Long-Term Follow-up After Pleural Infections—A Single-Center Experience with 536 Consecutive Patients Over 17 Years

PURPOSE: Pleural infections are associated with significant inflammation, long hospitalizations, frequent comorbidities, and are often treated operatively—all of which are consequential risk factors for thrombo-embolic complications. However, their occurrence following the treatment of pleural infec...

Descripción completa

Detalles Bibliográficos
Autores principales: Ala-Seppälä, Henna Maria, Ukkonen, Mika Tapani, Lehtomäki, Antti Ilmari, Pohja, Emilia Susanna, Nieminen, Jaakko Juhani, Laurikka, Jari Olavi, Khan, Jahangir Ari
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7374478/
https://www.ncbi.nlm.nih.gov/pubmed/32607673
http://dx.doi.org/10.1007/s00408-020-00374-x
_version_ 1783561707780571136
author Ala-Seppälä, Henna Maria
Ukkonen, Mika Tapani
Lehtomäki, Antti Ilmari
Pohja, Emilia Susanna
Nieminen, Jaakko Juhani
Laurikka, Jari Olavi
Khan, Jahangir Ari
author_facet Ala-Seppälä, Henna Maria
Ukkonen, Mika Tapani
Lehtomäki, Antti Ilmari
Pohja, Emilia Susanna
Nieminen, Jaakko Juhani
Laurikka, Jari Olavi
Khan, Jahangir Ari
author_sort Ala-Seppälä, Henna Maria
collection PubMed
description PURPOSE: Pleural infections are associated with significant inflammation, long hospitalizations, frequent comorbidities, and are often treated operatively—all of which are consequential risk factors for thrombo-embolic complications. However, their occurrence following the treatment of pleural infection is still unknown. The aim of the study was to ascertain the early and long-term occurrence of thrombo-embolic events in patients treated for pleural infections. METHODS: The study included all patients that were treated for pleural infections in Tampere University Hospital between January 2000 and December 2016. Data regarding later treatment episodes due to pulmonary embolisms and/or deep vein thromboses as well as survival data were requested from national registries. The rates were also compared to a demographically matched reference population adjusted for age, sex, and the location of residence. RESULTS: The final study population comprised 536 patients and 5318 controls (median age 60, 78% men). The most common etiology for pleural infection was pneumonia (73%) and 85% underwent surgical treatment for pleural infection. The occurrence of thrombo-embolic complications in patients and controls was 3.8% vs 0.1% at three months, 5.0% vs 0.4% at one year, 8.8% vs 1.0% at three years, and 12.4% vs 1.8% at five years, respectively, p < 0.001 each. Female sex, advanced age, chronic lung disease, immunosuppression, video-assisted surgery, and non-pneumonic etiology were associated with a higher incidence of thrombo-embolism. CONCLUSIONS: The occurrence of thrombo-embolic events—particularly pulmonary embolism but also deep vein thrombosis—was significant in patients treated for pleural infections, both initially and during long-term follow-up.
format Online
Article
Text
id pubmed-7374478
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Springer US
record_format MEDLINE/PubMed
spelling pubmed-73744782020-07-27 High Occurrence of Thrombo-Embolic Complications During Long-Term Follow-up After Pleural Infections—A Single-Center Experience with 536 Consecutive Patients Over 17 Years Ala-Seppälä, Henna Maria Ukkonen, Mika Tapani Lehtomäki, Antti Ilmari Pohja, Emilia Susanna Nieminen, Jaakko Juhani Laurikka, Jari Olavi Khan, Jahangir Ari Lung Pleural Infection and Thromboembolic Complications PURPOSE: Pleural infections are associated with significant inflammation, long hospitalizations, frequent comorbidities, and are often treated operatively—all of which are consequential risk factors for thrombo-embolic complications. However, their occurrence following the treatment of pleural infection is still unknown. The aim of the study was to ascertain the early and long-term occurrence of thrombo-embolic events in patients treated for pleural infections. METHODS: The study included all patients that were treated for pleural infections in Tampere University Hospital between January 2000 and December 2016. Data regarding later treatment episodes due to pulmonary embolisms and/or deep vein thromboses as well as survival data were requested from national registries. The rates were also compared to a demographically matched reference population adjusted for age, sex, and the location of residence. RESULTS: The final study population comprised 536 patients and 5318 controls (median age 60, 78% men). The most common etiology for pleural infection was pneumonia (73%) and 85% underwent surgical treatment for pleural infection. The occurrence of thrombo-embolic complications in patients and controls was 3.8% vs 0.1% at three months, 5.0% vs 0.4% at one year, 8.8% vs 1.0% at three years, and 12.4% vs 1.8% at five years, respectively, p < 0.001 each. Female sex, advanced age, chronic lung disease, immunosuppression, video-assisted surgery, and non-pneumonic etiology were associated with a higher incidence of thrombo-embolism. CONCLUSIONS: The occurrence of thrombo-embolic events—particularly pulmonary embolism but also deep vein thrombosis—was significant in patients treated for pleural infections, both initially and during long-term follow-up. Springer US 2020-06-30 2020 /pmc/articles/PMC7374478/ /pubmed/32607673 http://dx.doi.org/10.1007/s00408-020-00374-x Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Pleural Infection and Thromboembolic Complications
Ala-Seppälä, Henna Maria
Ukkonen, Mika Tapani
Lehtomäki, Antti Ilmari
Pohja, Emilia Susanna
Nieminen, Jaakko Juhani
Laurikka, Jari Olavi
Khan, Jahangir Ari
High Occurrence of Thrombo-Embolic Complications During Long-Term Follow-up After Pleural Infections—A Single-Center Experience with 536 Consecutive Patients Over 17 Years
title High Occurrence of Thrombo-Embolic Complications During Long-Term Follow-up After Pleural Infections—A Single-Center Experience with 536 Consecutive Patients Over 17 Years
title_full High Occurrence of Thrombo-Embolic Complications During Long-Term Follow-up After Pleural Infections—A Single-Center Experience with 536 Consecutive Patients Over 17 Years
title_fullStr High Occurrence of Thrombo-Embolic Complications During Long-Term Follow-up After Pleural Infections—A Single-Center Experience with 536 Consecutive Patients Over 17 Years
title_full_unstemmed High Occurrence of Thrombo-Embolic Complications During Long-Term Follow-up After Pleural Infections—A Single-Center Experience with 536 Consecutive Patients Over 17 Years
title_short High Occurrence of Thrombo-Embolic Complications During Long-Term Follow-up After Pleural Infections—A Single-Center Experience with 536 Consecutive Patients Over 17 Years
title_sort high occurrence of thrombo-embolic complications during long-term follow-up after pleural infections—a single-center experience with 536 consecutive patients over 17 years
topic Pleural Infection and Thromboembolic Complications
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7374478/
https://www.ncbi.nlm.nih.gov/pubmed/32607673
http://dx.doi.org/10.1007/s00408-020-00374-x
work_keys_str_mv AT alaseppalahennamaria highoccurrenceofthromboemboliccomplicationsduringlongtermfollowupafterpleuralinfectionsasinglecenterexperiencewith536consecutivepatientsover17years
AT ukkonenmikatapani highoccurrenceofthromboemboliccomplicationsduringlongtermfollowupafterpleuralinfectionsasinglecenterexperiencewith536consecutivepatientsover17years
AT lehtomakianttiilmari highoccurrenceofthromboemboliccomplicationsduringlongtermfollowupafterpleuralinfectionsasinglecenterexperiencewith536consecutivepatientsover17years
AT pohjaemiliasusanna highoccurrenceofthromboemboliccomplicationsduringlongtermfollowupafterpleuralinfectionsasinglecenterexperiencewith536consecutivepatientsover17years
AT nieminenjaakkojuhani highoccurrenceofthromboemboliccomplicationsduringlongtermfollowupafterpleuralinfectionsasinglecenterexperiencewith536consecutivepatientsover17years
AT laurikkajariolavi highoccurrenceofthromboemboliccomplicationsduringlongtermfollowupafterpleuralinfectionsasinglecenterexperiencewith536consecutivepatientsover17years
AT khanjahangirari highoccurrenceofthromboemboliccomplicationsduringlongtermfollowupafterpleuralinfectionsasinglecenterexperiencewith536consecutivepatientsover17years