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Challenges for Microelectronics in Non-Invasive Medical Diagnostics
Microelectronics is emerging, sometimes with changing fortunes, as a key enabling technology in diagnostics. This paper reviews some recent results and technical challenges which still need to be addressed in terms of the design of CMOS analog application specific integrated circuits (ASICs) and the...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7374509/ https://www.ncbi.nlm.nih.gov/pubmed/32610430 http://dx.doi.org/10.3390/s20133636 |
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author | Carminati, Marco Fiorini, Carlo |
author_facet | Carminati, Marco Fiorini, Carlo |
author_sort | Carminati, Marco |
collection | PubMed |
description | Microelectronics is emerging, sometimes with changing fortunes, as a key enabling technology in diagnostics. This paper reviews some recent results and technical challenges which still need to be addressed in terms of the design of CMOS analog application specific integrated circuits (ASICs) and their integration in the surrounding systems, in order to consolidate this technological paradigm. Open issues are discussed from two, apparently distant but complementary, points of view: micro-analytical devices, combining microfluidics with affinity bio-sensing, and gamma cameras for simultaneous multi-modal imaging, namely scintigraphy and magnetic resonance imaging (MRI). The role of integrated circuits is central in both application domains. In portable analytical platforms, ASICs offer miniaturization and tackle the noise/power dissipation trade-off. The integration of CMOS chips with microfluidics poses multiple open technological issues. In multi-modal imaging, now that the compatibility of the acquisition chains (thousands of Silicon Photo-Multipliers channels) of gamma detectors with Tesla-level magnetic fields has been demonstrated, other development directions, enabled by microelectronics, can be envisioned in particular for single-photon emission tomography (SPECT): a faster and simplified operation, for instance, to allow transportable applications (bed-side) and hardware pre-processing that reduces the number of output signals and the image reconstruction time. |
format | Online Article Text |
id | pubmed-7374509 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-73745092020-08-05 Challenges for Microelectronics in Non-Invasive Medical Diagnostics Carminati, Marco Fiorini, Carlo Sensors (Basel) Article Microelectronics is emerging, sometimes with changing fortunes, as a key enabling technology in diagnostics. This paper reviews some recent results and technical challenges which still need to be addressed in terms of the design of CMOS analog application specific integrated circuits (ASICs) and their integration in the surrounding systems, in order to consolidate this technological paradigm. Open issues are discussed from two, apparently distant but complementary, points of view: micro-analytical devices, combining microfluidics with affinity bio-sensing, and gamma cameras for simultaneous multi-modal imaging, namely scintigraphy and magnetic resonance imaging (MRI). The role of integrated circuits is central in both application domains. In portable analytical platforms, ASICs offer miniaturization and tackle the noise/power dissipation trade-off. The integration of CMOS chips with microfluidics poses multiple open technological issues. In multi-modal imaging, now that the compatibility of the acquisition chains (thousands of Silicon Photo-Multipliers channels) of gamma detectors with Tesla-level magnetic fields has been demonstrated, other development directions, enabled by microelectronics, can be envisioned in particular for single-photon emission tomography (SPECT): a faster and simplified operation, for instance, to allow transportable applications (bed-side) and hardware pre-processing that reduces the number of output signals and the image reconstruction time. MDPI 2020-06-29 /pmc/articles/PMC7374509/ /pubmed/32610430 http://dx.doi.org/10.3390/s20133636 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Carminati, Marco Fiorini, Carlo Challenges for Microelectronics in Non-Invasive Medical Diagnostics |
title | Challenges for Microelectronics in Non-Invasive Medical Diagnostics |
title_full | Challenges for Microelectronics in Non-Invasive Medical Diagnostics |
title_fullStr | Challenges for Microelectronics in Non-Invasive Medical Diagnostics |
title_full_unstemmed | Challenges for Microelectronics in Non-Invasive Medical Diagnostics |
title_short | Challenges for Microelectronics in Non-Invasive Medical Diagnostics |
title_sort | challenges for microelectronics in non-invasive medical diagnostics |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7374509/ https://www.ncbi.nlm.nih.gov/pubmed/32610430 http://dx.doi.org/10.3390/s20133636 |
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