Distinct and stage-specific contributions of TET1 and TET2 to stepwise cytosine oxidation in the transition from naive to primed pluripotency

Cytosine DNA bases can be methylated by DNA methyltransferases and subsequently oxidized by TET proteins. The resulting 5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC), and 5-carboxylcytosine (5caC) are considered demethylation intermediates as well as stable epigenetic marks. To dissect the...

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Detalles Bibliográficos
Autores principales: Mulholland, Christopher B., Traube, Franziska R., Ugur, Enes, Parsa, Edris, Eckl, Eva-Maria, Schönung, Maximilian, Modic, Miha, Bartoschek, Michael D., Stolz, Paul, Ryan, Joel, Carell, Thomas, Leonhardt, Heinrich, Bultmann, Sebastian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7374584/
https://www.ncbi.nlm.nih.gov/pubmed/32694513
http://dx.doi.org/10.1038/s41598-020-68600-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7374584/
https://www.ncbi.nlm.nih.gov/pubmed/32694513
http://dx.doi.org/10.1038/s41598-020-68600-3

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