Cargando…
Correlation between serum IL-32 concentration and clinical parameters of stable COPD: a retrospective clinical analysis
This study was to investigate the association between serum interleukin 32 (IL-32) concentration and clinical parameters in patients with stable chronic obstructive pulmonary disease (COPD). One hundred and sixteen patients with stable COPD and 70 healthy subjects were included in the study. The ser...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7374623/ https://www.ncbi.nlm.nih.gov/pubmed/32694699 http://dx.doi.org/10.1038/s41598-020-69000-3 |
_version_ | 1783561733379457024 |
---|---|
author | Rong, Biaoxue Fu, Tian Rong, Congxue Liu, Wen Li, Kai Liu, Hua |
author_facet | Rong, Biaoxue Fu, Tian Rong, Congxue Liu, Wen Li, Kai Liu, Hua |
author_sort | Rong, Biaoxue |
collection | PubMed |
description | This study was to investigate the association between serum interleukin 32 (IL-32) concentration and clinical parameters in patients with stable chronic obstructive pulmonary disease (COPD). One hundred and sixteen patients with stable COPD and 70 healthy subjects were included in the study. The serum concentration of IL-32 was detected by enzyme-linked immunosorbent assay. The correlation between serum IL-32 and clinical parameters of patients with COPD was analyzed by T-test, one-way analysis of variance, multiple linear regression and receiver operating characteristic curve. The serum concentration of IL-32 in patients with stable COPD was higher than that in healthy control group (p < 0.001) and increased serum IL-32 was positively correlated with GOLD grading (p = 0.026), mMRC score (p = 0.004) and clinical medical history (p = 0.005), but negatively related to FEV1/FVC (p = 0.001) and FEV1% predicted (p = 0.001). Patient's COPD grading (p = 0.001), clinical medical history (p < 0.001) and FEV1/FVC (p = 0.001) exerted a significant impact on serum IL-32. The sensitivity and specificity of serum IL-32 for discerning COPD patients from healthy individuals were 85.34% and 64.29%, and the area under the curve was 0.808 (p < 0.001). Increased IL-32 is involved in the chronic disease progression of COPD, suggesting that IL-32 may be a molecular biomarker that reflects the severity of COPD and contributes to the disease diagnosis. |
format | Online Article Text |
id | pubmed-7374623 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-73746232020-07-22 Correlation between serum IL-32 concentration and clinical parameters of stable COPD: a retrospective clinical analysis Rong, Biaoxue Fu, Tian Rong, Congxue Liu, Wen Li, Kai Liu, Hua Sci Rep Article This study was to investigate the association between serum interleukin 32 (IL-32) concentration and clinical parameters in patients with stable chronic obstructive pulmonary disease (COPD). One hundred and sixteen patients with stable COPD and 70 healthy subjects were included in the study. The serum concentration of IL-32 was detected by enzyme-linked immunosorbent assay. The correlation between serum IL-32 and clinical parameters of patients with COPD was analyzed by T-test, one-way analysis of variance, multiple linear regression and receiver operating characteristic curve. The serum concentration of IL-32 in patients with stable COPD was higher than that in healthy control group (p < 0.001) and increased serum IL-32 was positively correlated with GOLD grading (p = 0.026), mMRC score (p = 0.004) and clinical medical history (p = 0.005), but negatively related to FEV1/FVC (p = 0.001) and FEV1% predicted (p = 0.001). Patient's COPD grading (p = 0.001), clinical medical history (p < 0.001) and FEV1/FVC (p = 0.001) exerted a significant impact on serum IL-32. The sensitivity and specificity of serum IL-32 for discerning COPD patients from healthy individuals were 85.34% and 64.29%, and the area under the curve was 0.808 (p < 0.001). Increased IL-32 is involved in the chronic disease progression of COPD, suggesting that IL-32 may be a molecular biomarker that reflects the severity of COPD and contributes to the disease diagnosis. Nature Publishing Group UK 2020-07-21 /pmc/articles/PMC7374623/ /pubmed/32694699 http://dx.doi.org/10.1038/s41598-020-69000-3 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Rong, Biaoxue Fu, Tian Rong, Congxue Liu, Wen Li, Kai Liu, Hua Correlation between serum IL-32 concentration and clinical parameters of stable COPD: a retrospective clinical analysis |
title | Correlation between serum IL-32 concentration and clinical parameters of stable COPD: a retrospective clinical analysis |
title_full | Correlation between serum IL-32 concentration and clinical parameters of stable COPD: a retrospective clinical analysis |
title_fullStr | Correlation between serum IL-32 concentration and clinical parameters of stable COPD: a retrospective clinical analysis |
title_full_unstemmed | Correlation between serum IL-32 concentration and clinical parameters of stable COPD: a retrospective clinical analysis |
title_short | Correlation between serum IL-32 concentration and clinical parameters of stable COPD: a retrospective clinical analysis |
title_sort | correlation between serum il-32 concentration and clinical parameters of stable copd: a retrospective clinical analysis |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7374623/ https://www.ncbi.nlm.nih.gov/pubmed/32694699 http://dx.doi.org/10.1038/s41598-020-69000-3 |
work_keys_str_mv | AT rongbiaoxue correlationbetweenserumil32concentrationandclinicalparametersofstablecopdaretrospectiveclinicalanalysis AT futian correlationbetweenserumil32concentrationandclinicalparametersofstablecopdaretrospectiveclinicalanalysis AT rongcongxue correlationbetweenserumil32concentrationandclinicalparametersofstablecopdaretrospectiveclinicalanalysis AT liuwen correlationbetweenserumil32concentrationandclinicalparametersofstablecopdaretrospectiveclinicalanalysis AT likai correlationbetweenserumil32concentrationandclinicalparametersofstablecopdaretrospectiveclinicalanalysis AT liuhua correlationbetweenserumil32concentrationandclinicalparametersofstablecopdaretrospectiveclinicalanalysis |