Selective protection of human cardiomyocytes from anthracycline cardiotoxicity by small molecule inhibitors of MAP4K4

Given the poor track record to date of animal models for creating cardioprotective drugs, human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) have been proposed as a therapeutically relevant human platform to guide target validation and cardiac drug development. Mitogen-Activated Protein K...

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Detalles Bibliográficos
Autores principales: Golforoush, Pelin A., Narasimhan, Priyanka, Chaves-Guerrero, Patricia P., Lawrence, Elsa, Newton, Gary, Yan, Robert, Harding, Sian E., Perrior, Trevor, Chapman, Kathryn L., Schneider, Michael D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7374628/
https://www.ncbi.nlm.nih.gov/pubmed/32694738
http://dx.doi.org/10.1038/s41598-020-68907-1

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