A structurally minimized yet fully active insulin based on cone-snail venom insulin principles

Human insulin and its current therapeutic analogs all show propensity, albeit varyingly, to self-associate into dimers and hexamers, which delays their onset of action and makes blood glucose management difficult for people with diabetes. Recently, we described a monomeric, insulin-like peptide in c...

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Detalles Bibliográficos
Autores principales: Xiong, Xiaochun, Menting, John G., Disotuar, Maria M., Smith, Nicholas A., Delaine, Carlie, Ghabash, Gabrielle, Agrawal, Rahul, Wang, Xiaomin, He, Xiao, Fisher, Simon J., MacRaild, Christopher A., Norton, Raymond S., Gajewiak, Joanna, Forbes, Briony E., Smith, Brian J., Safavi-Hemami, Helena, Olivera, Baldomero, Lawrence, Michael C., Hung-Chieh Chou, Danny
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7374640/
https://www.ncbi.nlm.nih.gov/pubmed/32483339
http://dx.doi.org/10.1038/s41594-020-0430-8

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