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Ascites-derived ALDH+CD44+ tumour cell subsets endow stemness, metastasis and metabolic switch via PDK4-mediated STAT3/AKT/NF-κB/IL-8 signalling in ovarian cancer

BACKGROUND: Ovarian cancer is characterised by frequent recurrence due to persistent presence of residual cancer stem cells (CSCs). Here, we identify and characterise tumour subsets from ascites-derived tumour cells with stemness, metastasis and metabolic switch properties and to delineate the invol...

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Detalles Bibliográficos
Autores principales:	Jiang, Yu-Xin, Siu, Michelle Kwan-Yee, Wang, Jing-Jing, Mo, Xue-Tang, Leung, Thomas Ho-Yin, Chan, David Wai, Cheung, Annie Nga-Yin, Ngan, Hextan Yuen-Sheung, Chan, Karen Kar-Loen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7374705/ https://www.ncbi.nlm.nih.gov/pubmed/32390009 http://dx.doi.org/10.1038/s41416-020-0865-z

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