Ethanol exposure increases mutation rate through error-prone polymerases

Ethanol is a ubiquitous environmental stressor that is toxic to all lifeforms. Here, we use the model eukaryote Saccharomyces cerevisiae to show that exposure to sublethal ethanol concentrations causes DNA replication stress and an increased mutation rate. Specifically, we find that ethanol slows do...

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Detalles Bibliográficos
Autores principales: Voordeckers, Karin, Colding, Camilla, Grasso, Lavinia, Pardo, Benjamin, Hoes, Lore, Kominek, Jacek, Gielens, Kim, Dekoster, Kaat, Gordon, Jonathan, Van der Zande, Elisa, Bircham, Peter, Swings, Toon, Michiels, Jan, Van Loo, Peter, Nuyts, Sandra, Pasero, Philippe, Lisby, Michael, Verstrepen, Kevin J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7374746/
https://www.ncbi.nlm.nih.gov/pubmed/32694532
http://dx.doi.org/10.1038/s41467-020-17447-3

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