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Selection of mutant µplasmin for amyloid-β cleavage in vivo

One of the main culprits of Alzheimer’s disease (AD) is the formation of toxic amyloid-β (Aβ) peptide polymers and the aggregation of Aβ to form plaques in the brain. We have developed techniques to purify the catalytic domain of plasmin, micro-plasmin (µPlm), which can be used for an Aβ-clearance b...

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Detalles Bibliográficos
Autores principales:	Yang, Dongying, Zhu, Wei, Wang, Yingjie, Tan, Fangmei, Ma, Zhiping, Gao, Jiali, Lin, Xinli
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7374754/ https://www.ncbi.nlm.nih.gov/pubmed/32694536 http://dx.doi.org/10.1038/s41598-020-69079-8

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