Ex vivo cultivated oral mucosal epithelial cell transplantation for limbal stem cell deficiency: a review

Destruction or dysfunction of limbal epithelial stem cells (LESCs) leads to unilateral or bilateral limbal stem cell deficiency (LSCD). Fifteen years have passed since the first transplantation of ex vivo cultivated oral mucosal epithelial cells (COMET) in humans in 2004, which represents the first...

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Autores principales: Cabral, Joao Victor, Jackson, Catherine Joan, Utheim, Tor Paaske, Jirsova, Katerina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7374839/
https://www.ncbi.nlm.nih.gov/pubmed/32693830
http://dx.doi.org/10.1186/s13287-020-01783-8
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author Cabral, Joao Victor
Jackson, Catherine Joan
Utheim, Tor Paaske
Jirsova, Katerina
author_facet Cabral, Joao Victor
Jackson, Catherine Joan
Utheim, Tor Paaske
Jirsova, Katerina
author_sort Cabral, Joao Victor
collection PubMed
description Destruction or dysfunction of limbal epithelial stem cells (LESCs) leads to unilateral or bilateral limbal stem cell deficiency (LSCD). Fifteen years have passed since the first transplantation of ex vivo cultivated oral mucosal epithelial cells (COMET) in humans in 2004, which represents the first use of a cultured non-limbal autologous cell type to treat bilateral LSCD. This review summarizes clinical outcomes from COMET studies published from 2004 to 2019 and reviews results with emphasis on the culture methods by which grafted cell sheets were prepared.
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spelling pubmed-73748392020-07-22 Ex vivo cultivated oral mucosal epithelial cell transplantation for limbal stem cell deficiency: a review Cabral, Joao Victor Jackson, Catherine Joan Utheim, Tor Paaske Jirsova, Katerina Stem Cell Res Ther Review Destruction or dysfunction of limbal epithelial stem cells (LESCs) leads to unilateral or bilateral limbal stem cell deficiency (LSCD). Fifteen years have passed since the first transplantation of ex vivo cultivated oral mucosal epithelial cells (COMET) in humans in 2004, which represents the first use of a cultured non-limbal autologous cell type to treat bilateral LSCD. This review summarizes clinical outcomes from COMET studies published from 2004 to 2019 and reviews results with emphasis on the culture methods by which grafted cell sheets were prepared. BioMed Central 2020-07-21 /pmc/articles/PMC7374839/ /pubmed/32693830 http://dx.doi.org/10.1186/s13287-020-01783-8 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Cabral, Joao Victor
Jackson, Catherine Joan
Utheim, Tor Paaske
Jirsova, Katerina
Ex vivo cultivated oral mucosal epithelial cell transplantation for limbal stem cell deficiency: a review
title Ex vivo cultivated oral mucosal epithelial cell transplantation for limbal stem cell deficiency: a review
title_full Ex vivo cultivated oral mucosal epithelial cell transplantation for limbal stem cell deficiency: a review
title_fullStr Ex vivo cultivated oral mucosal epithelial cell transplantation for limbal stem cell deficiency: a review
title_full_unstemmed Ex vivo cultivated oral mucosal epithelial cell transplantation for limbal stem cell deficiency: a review
title_short Ex vivo cultivated oral mucosal epithelial cell transplantation for limbal stem cell deficiency: a review
title_sort ex vivo cultivated oral mucosal epithelial cell transplantation for limbal stem cell deficiency: a review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7374839/
https://www.ncbi.nlm.nih.gov/pubmed/32693830
http://dx.doi.org/10.1186/s13287-020-01783-8
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